Apoptosis induced by NS1 gene of Canine Parvovirus-2 is caspase dependent and p53 independent (original) (raw)
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The study investigates the role of the NS1 gene of Canine Parvovirus-2 (CPV-2) in inducing apoptosis in HeLa cells. It demonstrates that CPV-2.NS1 initiates apoptosis through a caspase-dependent mechanism, while operating independently of the p53 pathway. Experimental assays including flow cytometry, cell viability tests, and DNA fragmentation assays were employed to ascertain the apoptotic effects, revealing significant increases in apoptosis markers over time. Findings suggest potential implications for understanding viral pathogenicity and developing therapeutic strategies against CPV-2.
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