A Study of Haematological Manifestations of Sle with Special Reference to Disease Activity (original) (raw)
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International journal of research publications, 2022
Systemic Lupus Erythematosus (SLE) is an autoimmune illness with a broad range of clinical manifestations, one of which is hematological manifestations that cause high morbidity and mortality if there is a delay in diagnosis. This research was conducted to analyze the pattern of hematological manifestations of SLE patients. This research was a descriptive retrospective study. A total of 106 patients with systemic lupus erythematosus met the inclusion criteria. Patients were dominated by a female (94.34%) and the age group of 18-27 years old (46.23%). The average hemoglobin level of the sample was 8.16 g/dl with anemia in 99 patients (93.4%), which was morphologically dominated by normochromic normocytic anemia in 61 patients (57.55%). The mean platelet count of the sample was 192.77 x and thrombocytopenia was found in 26 patients (24.53%). The mean lymphocyte count of the sample was 1.03 x and lymphopenia was found in 26 patients (79.25%). The mean leukocyte count in the sample was 7.53 x and leukopenia was found in 22 patients (20.75%). This study concludes that SLE patients are dominated by females aged 18-27 years old and the most frequent hematological abnormalities are anemia (morphologically dominated by normochromic normocytic anemia), thrombocytopenia, lymphopenia, and leukopenia.
Haematological abnormalities in systemic lupus erythematosus
2014
OBJECTIVES This study was conducted to evaluate the frequency and pattern of haematological abnormalities (HA) in SLE patients at the time of diagnosis and last follow-up, and their relationship with organ involvement. PATIENTS AND METHODS This retrospective study included patients who were diagnosed and treated for SLE from 1982 to 2008 at King Khalid University hospital, Riyadh. Demographic and haematological parameters at diagnosis and the last follow-up, disease manifestations, organ involvement and clinical hematological complications were recorded. Association of HA with organ involvement was explored by multivariate analysis. RESULTS A total of 624 patients (90.7% females, mean age 34.3±11.9 years) were studied. HA were present in 516 (82.7 %) patients at the time of diagnosis. Anemia was the most frequent HA in 63.0% patients followed by lymphopenia in 40.3%, leukopenia in 30.0%, thrombocytopenia in 10.9% and autoimmune hemolytic anemia (AIHA) in 4.6% patients. Deep vein thr...
Chattagram Maa-O-Shishu Hospital Medical College Journal, 2014
Hematological abnormalities are frequently encountered in patients with SLE. It was aimed to study the pattern and frequency of hematological abnormalities in patients with SLE. Forty patients were prospectively analyzed who were suffering from SLE in the CMCH over a period of one year. All patients were evaluated according to the case record form with particular reference to hematological manifestations. Most patients were females in the child bearing age. Hematological manifestations were documented in87.5% of patients. Anemia was the most common hematological abnormality detected (57.5%). Iron deficiency anemia(IDA) 60%, Anemia of chronic disease(ACD) 26.9% and Autoimmune hemolytic anemia(AIHA) 8.7 % were the most common cause of anemia detected. The data demonstrated that while hematological manifestations are very common in SLE but they are rarely life threatening.
HAEMATOLOGICAL VARIABLES IN SYSTEMIC LUPUS ERYTHEMATOSUS.pdf
The study was done to determine changes in some haematological variables in patients suffering from systemic lupus erythematosus in Imo State,Nigeria.A total of seventy (70) subjects were recuited for the study.Five (5) females were subjects suffering from systemic lupus erythematosus and sixty five (65) subjects were non-systemic lupus erythematosus females as the controls.Full blood count, erythrocyte sedimentation rate, platelet count of sufferers, and non-sufferers who served as control were determined using standard haematologic methods. t-test analysis revealed significant statistical differences in all variables (P<0.05) except eosinophll in SLE (P>0.05). Anaemia, leukaemia and thrombocytopenia were seen in some percentage of patients.Haemato logic surveillance in systemic lupus erythematosus disease, and instituting systemic lupus erythematosus disease magement programme will assist in reducing complications that may be brought about by haematologic changes and ignorance.
Hematology, 2007
Abnormalities of hematological system are very common in systemic lupus erythematosus (SLE). The aim of the study is to evaluate hematological findings in patients with SLE at the time of referral and their relationship with disease activity and organ involvement. The study was carried consecutive 115 patients, including 20 males and 85 females. Most of the cases had anemia at the time of presentation due to various etiologies. Anemia of chronic disease was seen in 46% and it was the most common encountered picture. The rate of hemolytic anemia was 28%, and Coombs' positivity rate was 22% among our patients. Leukopenia (,4.0 £ 10 9 /l), neutropenia (, 1.8 £ 10 9 /l), and lymphopenia (, 1.5 £ 10 9 /l) rates were 57, 20, and 82%, respectively. Thrombocytopenia was seen in 40% for , 150 £ 10 9 /l, 26% for ,100 £ 10 9 /l, and 8% for , 50 £ 10 9 /l. Of our patients, 10% had antiphospholipid syndrome (APS) at the time of diagnosis. Increased fibrinogen levels were observed in 35% without relating to disease activity. The rates of C3 and C4 hypocomplementemia were 86 and 64%, respectively, and both are closely correlated with the disease activity. Moreover, C3 hypocomplementemia was more prominent in cases with renal or serosal involvement. Leukopenia and hyperfibrinogenemia were more common in patients with skin/mucosal involvements. C3 hypocomplementemia, APS and elevated IgG levels were more common in our patients with renal involvement. SLE should be kept in mind while evaluating patients with mentioned hematological findings, especially in those with accompanying organ involvements.
A Practical Perspective of the Hematologic Manifestations of Systemic Lupus Erythematosus
Cureus, 2022
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with an unknown etiology that can affect any organ or system of the human body. Hematological, renal, or central nervous system manifestations in these patients result in great morbidity because high doses of glucocorticoids, cytotoxic medications, or biological drugs are required to control these manifestations. It is noteworthy that hematological involvement predominates during the first years of the disease and tends to last over time, with the premise that it may be the initial manifestation of the disease. Clear examples of this are the cases of hemolytic anemia and immune thrombocytopenia that can be initially classified as idiopathic or primary to be later classified as secondary when associated with infections, medications, neoplasms, or autoimmune diseases. The spectrum of hematologic manifestations in SLE is very broad, including lymphopenia, anemia, thrombocytopenia, or pancytopenia. In some cases, lymphadenopathy and splenomegaly are also identified. The vast majority of these manifestations denote high disease activity. However, many of these alterations have a multifactorial cause that must be taken into account to adopt a more complete therapeutic approach. The objective of this review is to characterize in detail the hematological manifestations of SLE to offer clinicians a practical vision of its diagnosis and treatment.
2016
Background: Haematological abnormalities are the most common manifestations of Systemic Lupus Erythematosus (SLE). Anaemia of Chronic Disease (ACD) has been associated with significantly higher disease activity. Thrombocytopenia early in the course of disease is indicative of more severe active disease and if severe it is an independent predictor of damage accrual and mortality. Leucopenia usually reflects disease activity. Objectives: To determine the prevalence of haematological abnormalities, among SLE patients on follow up at Rheumatology and Renal Outpatient clinics at Kenyatta National Hospital. Specifically, the study aimed to describe the prevalence of anaemia, leucopenia, and thrombocytopenia and identify patient factors associated with these abnormalities. Design: Cross-sectional hospital based descriptive study. Setting: Rheumatology out-patient clinic and Renal out-patient clinic at KNH. Subjects: Sixty five patients who fulfilled the 1997 American College of Rheumatolog...
Haematological manifestations of lupus
Lupus science & medicine, 2015
Our purpose was to compile information on the haematological manifestations of systemic lupus erythematosus (SLE), namely leucopenia, lymphopenia, thrombocytopenia, autoimmune haemolytic anaemia (AIHA), thrombotic thrombocytopenic purpura (TTP) and myelofibrosis. During our search of the English-language MEDLINE sources, we did not place a date-of-publication constraint. Hence, we have reviewed previous as well as most recent studies with the subject heading SLE in combination with each manifestation. Neutropenia can lead to morbidity and mortality from increased susceptibility to infection. Severe neutropenia can be successfully treated with granulocyte colony-stimulating factor. While related to disease activity, there is no specific therapy for lymphopenia. Severe lymphopenia may require the use of prophylactic therapy to prevent select opportunistic infections. Isolated idiopathic thrombocytopenic purpura maybe the first manifestation of SLE by months or even years. Some manifes...
Case Report on Systemic Lupus Erythematosus
Indian Journal of Forensic Medicine & Toxicology, 2020
Background: Systemic Lupus Erythematous (SLE) is a multi-system chronic but often episodic,autoimmune condition defined by widespread inflammation of connective tissues and immune complexmediated vasculitis as well as the involvement of Antinuclear Antibodies.Case Presentation: The 11 years old female patient who was apparently alright 2 months back admittedin “Acharya Vinoba Bhave Rural Hospital Sawangi (M), Wardha,” Maharashtra on date 22/02/2020 withthe chief complaint of high-grade fever on and off since 2 months and facial puffiness since 6 days, ascites,constipation and pain in joints. The patient started experiencing fever 02 months back which was highgrade and she took treatment on an OPD basis but there was no relief. After that she was admitted at GMCChandrapur for the complaint of cough, cold, fever and oral ulcer and symptomatic treatment was given andgot discharged after 12 days. Fever, facial puffiness, pain in knee joints. The patient had undergone variousinvestigatio...
Journal of Advances in Medicine and Medical Research
Background: Lupus erythematosus is a diverse autoimmune disorder that is capable of afflicting a variety of organs and has a clinical history that is inconsistent. Despite substantial improvements in systemic lupus erythematosus (SLE) patient survival, the pathophysiology of the disease remains unexplained, despite the fact that genes play a key role in its propensity. Objective: To evaluate the several hematological indicators (neutrophil- to- lymphocyte ratio (NLR), platelet -to- lymphocyte ratio (PLR), platelet distribution width (PDW), red cell distribution width (RDW), mean platelet volume (MPV) in SLE patients and their correlation with disease manifestations. Patients and Methods: In our study, a cross-sectional comparative study that enrolled 100 SLE patients (30 male and 70 female patients) aged from 18-55y who are recruited from the Internal Medicine Department, Rheumatology Unit (inpatient wards and outpatient clinics) the patients were categorized into three groups accor...