Multi-centre study on the evaluation of alcohol dehydrogenase activity in the serum of horses with intestinal strangulation (original) (raw)
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Journal of Veterinary Emergency and Critical Care, 2011
Objectives -To measure serum alcohol dehydrogenase (ADH) activity in horses with acute intestinal obstruction and to determine the diagnostic and prognostic utility of this analyte. Design -Prospective observational study. Setting -University Veterinary Hospital. Animals -Thirty healthy horses (control group) and 77 horses with acute intestinal obstruction, including 36 horses with nonstrangulating obstruction (23 with left ventral colon impaction and 13 with left dorsal displacement [G1], 22 with small intestinal strangulation [G2], and 19 with colon torsion [G3]).
Ciência Animal Brasileira, 2011
This study aimed to evaluate the parameters of renal and hepatic functions in horses submitted to an experimental model of intestinal obstruction. Twenty-four animals were distributed into four different groups: instrumented control (GI), duodenum obstruction (GII), ileum obstruction (GIII) and large colon obstruction (GIV). Blood samples were collected one hour before the surgical procedure (T0); 3 hours after the obstruction/ischemia (T3i); and 1, 3, 12, 24, 72 and 120 hours after the beginning of deobstruction/reperfusion for determination of the concentration of urea, creatinine, aspartate aminotransferase, gamma-glutamyltransferase, alkaline phosphatase, albumin, glucose, fibrinogen and (total,
2012
We examined 46 adult horses - six healthy, as control, (group 1), and 40 horses with colic submitted to treatment by laparotomy. Twenty animals had no postoperative complication (group 2), and twenty died or were euthanized from seven to ten days after the surgery (group 3). There was an increase in serum urea and creatinine concentration and AST, FA and GGT activity of animals from group 1 and group 2, indicative of renal and hepatic injury. The changes were associated with dehydration and endotoxins. Depending on the severity of the colic, animals may develop kidney and liver failure.
Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2014
The initial inflammatory stages of the colic syndrome include changes known as acute phase response. The aim of this study was to contribute with the establishment of reference values concerning the electrophoretogram of peritoneal liquid from healthy horses and horses submitted to experimentally induced intestinal obstruction. Twenty-one horses were allotted in four groups: duodenal obstruction (DG), ileum obstruction (IG), left-dorsal colon obstruction (MG), and control group (CG). Peritoneal liquid was sampled before obtruction (T0), with 3 hours of obstruction (T3) and 6, 30, 102 and 174 hours after desobstructing (T6, T30, T102 and T174, respectively). Total protein levels were determined by the biuret method and protein fractions were obtained by SDS-PAGE electrophoresis. The acute phase proteins (APP) identified were Immunoglobulin-A, ceruloplasmin, transferrin, albumin, α1-antitrypsin, heavy and light chains of immunoglobulin-G, haptoglobin, α1-acid glycoprotein and a still ...
Survival after Small Intestine Resection and Anastomosis in Horses
Veterinary Surgery, 1990
The authors examined factors influencing survival in 140 horses that recovered from anesthesia after small intestinal resection between 1968 and 1986, using Kaplan‐Meier estimated survival curves and the Cox proportional hazards regression model. Seventy‐two horses (51%) died during the initial postoperative period, 19 horses (14%) died after discharge from the hospital, 33 horses (24%) were alive, and 16 horses (11%) were classified as censored. Mean age at surgery was 8 years. Horses 15 years of age or older, Arabians and Stallions, were overrepresented in the hospital population. The most common reason for resection was strangulation of bowel through a mesenteric rent. The mean and 50% median survival times were 1540 and 27 days, respectively. Horses admitted after January 1, 1980, had a significantly longer survival than those admitted before that time. Survival was longer after anastomosis of two small intestinal segments than after anastomosis of a small intestinal segment to ...
Canadian journal of veterinary research = Revue canadienne de recherche vétérinaire, 1999
The purpose of this study was to determine whether nitric oxide (NO) is present in clinically normal horses under basal conditions and if it increases secondary to naturally acquired small intestinal strangulation obstruction. Thirty-one horses were used; 20 horses with naturally acquired small intestinal strangulation obstruction and 11 clinically normal horses with no signs of gastrointestinal tract disease. Jugular venous blood, abdominal fluid, and urine were collected for NO quantification. Plasma, abdominal fluid, and urine were stored at -70 degrees C until analyzed for NO using a chemiluminescent method. Biopsy specimens collected from the affected jejunal segment, during anesthesia or after immediately after euthanasia, or from the midjejunum of control horses, were divided into subsections for fixation in zinc formalin and cryopreservation in OCT gel. Nicotinamide adenine dinucleotide phosphate (reduced) (NADPH) diaphorase histochemical stains were performed on cryopreserv...
Revista Acadêmica: Ciência Animal, 2012
Previous reports of duodenitis-proximal jejunitis (DPJ) have noted histopathologic changes in the liver. However, there have been few studies evaluating the hepatic function during the process of DPJ in horses. The objective of this study was to investigate the hypotheses that there is a correlation between DPJ and hepatic dysfunction. Blood samples from 8 horses with DPJ were collected for aspartate aminotransferase (AST), gama-glutamyl transferase (GGT), total (TB), direct (DB) and indirect bilirubin (IB), total serum protein and albumin analysis. The blood samples were collected from horses that survived on the moment of admission at the veterinary hospital, at the time of nasogastric reflux (NGR) end, and at the time the animals were allowed to eat. At the same time, heart rate, respiratory rate, rectal temperature and packed cell volume (PCV) were performed and the volume and duration of NGR were evaluated. Blood samples and parameters of horses that have died were collected at the moment of admission at the hospital. The values of respiratory rate, rectal temperature, volume of NGR, AST, GGT, total protein and albumin were not statistically significant during the trial. By the time of admission at the hospital, the values of heart rate and PCV were significantly greater in horses that have died compared to the survivors. In the survivors there were significant values for heart rate, PCV and for bilirubins. This study did not confirm the hypothesis that DPJ causes hepatic dysfunction in horses when serum biochemical analyses were performed.
Evaluation of risk factors associated with development of postoperative ileus in horses
Journal of the American Veterinary Medical Association, 2004
EQUINE P ostoperative ileus (POI) is a common and serious complication of surgery for horses with colic. Estimated prevalences or incidences of POI among horses with colic have ranged from 10% to 20%. 1-5 To our knowledge, only 3 systematic evaluations have been conducted to identify factors predisposing to POI in horses. 2,3,6 Each of these 3 studies was conducted at a single institution and used a different definition of POI; 2 of the studies were retrospective in design.
Role of prokinetic drugs for treatment of postoperative ileus in the horse
Australian Veterinary Journal, 1998
All horses undergoing coeliotomy for an acute abdominal crisis are at risk of developing ileus and should receive therapy aimed at promoting gastrointestinal function by restoring fluid and electrolyte balance. Adequate analgesia and prevention against peritonitis, bacteraemia and endotoxaemia should be provided. Horses that at the time of surgery have a strangulating or non-strangulating small intestinal obstruction should be considered to be at greater risk of developing a persistent ileus that is refractory to treatment than those horses with lesions involving the large intestine. In horses considered to be at greater risk of developing a persistent ileus, the use of prokinetic agents should be considered. Agents that may be used to improve gastrointestinal motility include adrenergic receptor antagonists, cholinergic agonists, benzamides, dopamine antagonists, macrolide antimicrobials, opiate receptor agonists and antagonists, somatostatin analogues and local anaesthetics. There are limited studies into the use of these agents in the horse. Until further research provides more information on motility disorders following intestinal surgery and the efficacy of prokinetic agents in this species, only selective use of some of these drugs can be recommended. Aust Vet J 1998;76:25-31