Effect of Non-Surgical Periodontal Treatment on Clinical and Biochemical Risk Markers of Cardiovascular Disease: A Randomized Trial (original) (raw)
Related papers
Journal of Investigative and Clinical Dentistry, 2019
Objective: To assess visfatin concentration in serum and gingival crevicular fluid (GCF) and investigate their relationship in chronic periodontitis patients with type 2 diabetes mellitus (T2DM) before and after non-surgical periodontal treatment. Methods: Fifty-four chronic periodontitis patients with T2DM were recruited. The patients were randomly divided into two groups: treatment group and control group. The serum and GCF visfatin concentration and the HbAlc level were measured by ELISA at different time points (baseline, and after 3 and 6 months of non-surgical periodontal treatment). Results: The serum and GCF visfatin concentration showed no significantly different between two groups at baseline (t test, P > 0.05). A significant decline of visfatin in treatment group was found in serum and GCF after 3 months of non-surgical periodontal treatment (t test, P < 0.01). The baseline and 3 month HbAlc levels were not significantly different, but at six months, a statistically significant difference was detected (t test, P > 0.05). Conclusion: Our data suggested that non-surgical periodontal treatment is helpful for glucose control, which may be associated with the reduced visfatin in periodontitis of T2DM patients. Furthermore, it suggested that visfatin may be considered as an inflammatory marker for periodontal diseases.
Journal of Periodontology, 2012
Background: Levels of visfatin in serum and gingival crevicular fluid (GCF) were explored in patients with periodontal health, periodontal disease with and without type 2 diabetes mellitus (t2 DM) and were found to be elevated with periodontal disease, and were correlated with periodontal clinical parameters. DM and chronic periodontitis (CP) are associated with each other. Adipokines, specifically visfatin, are secreted from adipocytes and are thought to cause insulin resistance. The purpose of this study is to determine the presence of visfatin in serum and GCF in t2 DM among individuals with CP and to find an association, if any.
2021
The ability to correctly diagnose and institute effective periodontal therapy is essential to control periodontal diseases. Rapid advances in diagnostic research are moving towards methods whereby periodontal disease risk can be identified and quantified by measuring biomarkers. This study investigated the effect of Non-Surgical Periodontal Treatment (NSPT) on clinical indices and salivary levels of visfatin in subjects with increasing severity of the periodontal disease. This interventional clinical trial was performed on 60 systemically healthy male and female subjects (20 to 50 years) who were categorised into Group-1, Twenty subjects with healthy periodontium, Group-2, Twenty subjects with generalized moderate gingivitis, and Group-3 (20 subjects with moderate to severe periodontitis (Stage III according to the new classification of periodontal diseases). The visfatin levels were measured in unstimulated saliva by using standard Enzyme-Linked Immunosorbent Assay (ELISA) technique at baseline and six weeks after NSPT. The salivary visfatin levels were highest in Group-3 (38.22±3.38 ng/ml) followed by Group-2 (26.66±2.24 ng/ml) and Group-1 (25.60±2.19 ng/ml) at baseline. After NSPT statistically significant reduction in salivary visfatin levels (p<0.001) in Groups-2 and 3 were seen. Visfatin levels at baseline were almost equivocal in normal weight and overweight subjects, irrespective of body mass index and showed a statistically significant reduction in salivary visfatin levels in both groups six weeks after NSPT (p<0.001). The present study suggests that salivary visfatin is a strong contributor in the pathology of periodontal disease and can be used as its diagnostic/therapeutic biomarker.
Influence of Periodontal Disease on cardiovascular markers in Diabetes Mellitus patients
Scientific Reports
The objective of the present study was to establish if individuals with Diabetes Mellitus (DM2) and periodontal diseases (gingivitis or periodontitis) presented an increase in the concentration of modified LDL (moLDL) and what is the influence of periodontal treatment on the decrease of moLDL particles with consequent improvement in the parameters of DM2. Twenty-four diabetic patients with periodontitis (Group 1) and twenty-four diabetic patients with gingivitis (Group 2) were followed up for a period of 12 months. Group 1 was treated with periodontal debridement, and Group 2 received supra-gingival scaling and prophylaxis. In both groups, periodontal clinical parameters: probing depth (PD), clinical attachment level (CAL), gingival resection (GR), bleeding on probing index (BOP) and plaque index; inflammatory serum markers (glycemia, A1c, total cholesterol, HDL-cholesterol (HDL-c), LDL-cholesterol (LDL-c), triglycerides and hs-CRP) and oxidized LDL (oxLDL) were measured at baseline...
Immunohistochemical expression of visfatin in the gingival tissue of type II diabetes patients
Annals of Tropical Medicine and Public Health
Visfatin found to be associated with different systemic inflammatory diseases like diabetes and diseases of oral cavity like periodontal diseases so that the aim of this study to evaluate the expression of visfatin in the gingival tissue of control and uncontrolled type 2 diabetic patients. 28 type 2 diabetic patients divided into two groups, the first group consist of 18 control diabetic patients under hypoglycemic drug with chronic periodontitis, the second group which also consist of 18 patients but an uncontrolled diabetic(without hypoglycemic drug) and with chronic periodontitis and the third group 10 person with healthy periodontium. Their age was between (30-45) years and all patients in both groups were male and non-smokers. The periodontal condition was estimated by recording the plaque index, bleeding on probing, probing pocket depth and clinical attachment level. Gingival pocket epithelium samples were excised crown lengthening procedure and periodontal flap surgery in the diabetic group and healthy groups and then processed for hematoxylin and eosin staining then immunohistochemical staining for visfatin marker expression. Statistical analysis was done by using SPSS software and paired t-test, Mann-Whitney test. Statistically significant was considered at a p-value less than 0.05. The mean value of all recorded periodontal parameters was highest among uncontrolled diabetic group compared to control with statistically significant difference existed between both groups (p=0.000) for plaque index, bleeding on probing, probing pocket depth and clinical attachment level. In regard to the immunohistochemistry staining, the Mann-Whitney test was used and the results revealed significant differences between the diabetic groups (p= 0.000). In conclusion, the study revealed the poor condition of the oral cavity regarding the periodontal condition of patients with type 2 diabetes, so the cooperation between diabetic centers and dentists needs to be increased. The immunohistochemical stain for visfatin was found more intense in the gingival tissue of the uncontrolled diabetic group compared to the control diabetic one. So that visfatin may have a link to the etiology and pathology of type 2 diabetes and chronic periodontitis.
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH
Introduction: Non Surgical Periodontal Therapy (NSPT) has been an effective treatment for suppression of gingival inflammation and improvement of periodontal health in patients. Periodontitis and diabetes have an inter-relationship with each other. Surgical intervention is not always advisable for periodontitis with patients with diabetes. Hence, assessing the response of non surgical periodontal treatment in diabetic patients can lead to better and non invasive treatment options. Aim: To evaluate the effect of NSPT by observing changes in Gingival Index (GI), Plaque Index (PI), Clinical Attachment Loss (CAL), and volume of Gingival Crevicular Fluid (GCF) in diabetic and systemically healthy periodontitis patients. Materials and Methods: This was a prospective clinical study conducted in the Department of Periodontology, Rural Dental College, Loni, Maharashtra from January 2021 until June 2022. Total of 90 patients were assessed and were divided into three groups. Group A (n=30) inc...
2020
Background. This study investigated the effect of non-surgical periodontal treatment on clinical indices and salivary levels of visfatin, chemerin, and progranulin in diabetic patients with periodontitis. Methods. This interventional clinical trial was performed on 20 patients with type II diabetes mellitus (T2DM) with moderate to severe chronic periodontitis (periodontitis stages II or III according to the new classification of periodontal diseases). Clinical indices, including gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL) and plaque index (PI), were recorded and visfatin, chemerin, and progranulin adipokines levels were also measured in unstimulated saliva by ELISA technique at baseline and twelve weeks after non-surgical periodontal treatment. Results. GI dropped from 1.92±0.27 to 0.71±0.14 after the intervention (P<0.001). Also, there were significant changes in the PPD and PI (P<0.001). However, no significant changes were observed in th...
Diabetic and cardiovascular risk in patients diagnosed with periodontitis
Australian dental journal, 2014
There are well established associations between periodontitis and diabetes mellitus and cardiovascular disease (CVD). The literature suggests a reciprocal relationship between periodontitis and diabetes. This pilot study aimed to measure in individuals with moderate to severe periodontitis their diabetes and CVD risks METHODS: Participants with a diagnosis of periodontitis were recruited from the Royal Dental Hospital of Melbourne. Casual blood glucose (CBG), total cholesterol (TC), HbA1c, blood pressure (BP), weight, and height were measured for all study participants. Forty-two participants enrolled in our study out of 159 that were approached [mean age 51.3, 26 (61.9%) females]. Twenty-four (57.1%) patients were undiagnosed pre-diabetic and had an HbA1c of ≥ 5.7; three (7.15%) patients were undiagnosed diabetic with an HbA1c of ≥6.5. Fourteen (33.3%) patients were hypertensive (BP ≥ 140/90mmHg) and seventeen (40.5%) had hypercholesterolemia (TC ≥5.5). Twelve (28.6%) patients were...