Effect of Non-Surgical Periodontal Treatment on Clinical and Biochemical Risk Markers of Cardiovascular Disease: A Randomized Trial (original) (raw)

Objective: To assess visfatin concentration in serum and gingival crevicular fluid (GCF) and investigate their relationship in chronic periodontitis patients with type 2 diabetes mellitus (T2DM) before and after non-surgical periodontal treatment. Methods: Fifty-four chronic periodontitis patients with T2DM were recruited. The patients were randomly divided into two groups: treatment group and control group. The serum and GCF visfatin concentration and the HbAlc level were measured by ELISA at different time points (baseline, and after 3 and 6 months of non-surgical periodontal treatment). Results: The serum and GCF visfatin concentration showed no significantly different between two groups at baseline (t test, P > 0.05). A significant decline of visfatin in treatment group was found in serum and GCF after 3 months of non-surgical periodontal treatment (t test, P < 0.01). The baseline and 3 month HbAlc levels were not significantly different, but at six months, a statistically significant difference was detected (t test, P > 0.05). Conclusion: Our data suggested that non-surgical periodontal treatment is helpful for glucose control, which may be associated with the reduced visfatin in periodontitis of T2DM patients. Furthermore, it suggested that visfatin may be considered as an inflammatory marker for periodontal diseases.