Focus on Molecules: Rod photoreceptor cGMP-gated cation channel (original) (raw)
The rod photoreceptor cGMP-gated cation (rod CNG) channel is crucial for phototransduction and maintaining photoreceptor structural integrity. Composed of three α-subunits and one β-subunit, this non-selective cation channel plays diverse roles in both the visual and olfactory systems. Recent studies highlight the significance of the unique GARP region of the β-subunit and its interactions with other cellular proteins, which are vital for preserving the structural integrity of rod outer segments. Further research is needed to elucidate the high-resolution structure of the channel and the functional implications of its various components.