Prematurity Negatively Alters Activation of the Amino Acid Signaling Pathway That Regulates Protein Synthesis in Muscle of a Preterm Piglet Model (original) (raw)

Preterm birth is linked to decreased postnatal lean mass gain and anabolic resistance, primarily through impaired activation of the mTORC1 signaling pathway that regulates protein synthesis in skeletal muscle. In this study, the amino acid signaling components were evaluated in a preterm piglet model. Results showed that while amino acid transporter levels remained unchanged, the postprandial activation of mTORC1 was significantly lower in preterm compared to term piglets. This suggests that reduced activation of mTORC1 post feeding may contribute to growth challenges following preterm birth.