Formulation and Evaluation of Fixed-Dose Combination of Bilayer Gastroretentive Matrix Tablet Containing Atorvastatin as Fast-Release and Atenolol as Sustained-Release (original) (raw)
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The objective of this work was to formulate co-loaded bilayer tablets containing ezetimibe (EZB) and atorvastatin (ATC). ATC loaded in the immediate-release (IR) layer is an HMG CoA reductase inhibitor, while EZB, added in the sustained-release (SR) layer, is a lipid-lowering agent. This study was conducted to evaluate the effects of polymer on the formulation and characterization of bilayer tablets, as well as the therapeutic impact of the concurrent use of both drugs having a sequential release pattern. To obtain the optimized results, four different formulations with variable compositions were developed and evaluated for different parameters. The drug release studies were carried out using a type II dissolution apparatus, using phosphate buffer solution (PBS) of 1.2 pH for IR of EZB for an initial 2 h, followed by 24 h studies for ATC in PBS 6.8 pH. The IR layer showed rapid drug release (96%) in 2 h, while 80% of the ATC was released in 24 h from the SR layer. Locally obtained, ...
FORMULATION AND EVALUATION OF BILAYER FLOATING TABLETS OF ATORVASTATIN AND RAMIPRIL
Abstract: The aim of the present study is to formulate and evaluate the bilayer tablets of Atorvastatin and Ramipril using different media, to know the release studies in which media the release of the drug is in controlled manner. The bilayer tablets of Atorvastatin matrix floating and Ramipril immediate release tablets were prepared. Bi-Layer tablets consists of two layers i.e.,immediate release layer containing of disintegrant sodium starch glycollate and controlled release layer containing HPMCK100M, POLY0X WSR 303 and sodium alginate as retard layer. Combination of Atorvastatin and ramipril prepared by direct compression and wet granulation method which consists of various disintegrants and polymer in different ratios The tablets were evaluated for various parameters like weight variation, thickness, hardness and friability. The release studies were carried out using different media using USP dissolution testing apparatus II (paddle type) for 12hrs. Keywords: Bilayer tablets, Atorvastatin, Ramipril polymer.
https://www.ijrrjournal.com/IJRR\_Vol.9\_Issue.5\_May2022/IJRR-Abstract04.html, 2022
Dosage form tablets and capsules in the current era still have gained considerable importance and acceptance by the formulation scientists, physicians, and the patients due to their numerous advantages which include easy selfadministration and cost-effectiveness experienced by the patients. However, the drug delivery through the tablet dosage is no doubt, associated with potential drawbacks which include difficulty for the older and pediatric patients to swallow (dysphagia), low fraction of drug available for absorption in the bloodstream due to first-pass hepatic effect, and a slower therapeutic outcome in patients. Fast dissolving tablets have been emerged as a newer concept, in novel drug delivery systems that offer not only an alternative to conventional tablet dosage form, but also provide better therapeutic outcome, the ultimate solution, and a better option for the problem faced by the patients of such age group and diseases.
Evidence-Based Complementary and Alternative Medicine
The goal of this study was to develop atorvastatin (ATN) calcium biloaded, i.e., immediate release (IR) and sustained release (SR) capsules that would promote the quick onset of action and a better dissolution profile on both the IR and SR aspects. The IR granules were prepared by the wet granulation method, and an aqueous solubility study proved that the IR granules released the ATN within 25 min compared to the pure drug due to the addition of PEG and super disintegrants such as croscarmellose (CC) and crospovidone (CP). The sustained release nanoparticles (SR-NPs) were synthesized using a solvent evaporation technique and an optimal combination of hydrophilic and hydrophobic polymers. The addition of a hydrophobic polymer to a hydrophilic polymer delays drug release, resulting in a sustained and controlled release lasting up to 12 hours. The drug release of ATN from SR nanoparticles followed the Higuchi and Korsmeyer–Peppas models and had first-order kinetics (r2 = ???). Fourier ...
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The aim of our research work was to formulate and evaluate sustained release tablets of atorvastatin using the biomaterial as a novel bio-binder for the formulation of tablets. The bio-material was isolated from the unripe fruit pulp of Artocarpus heterophyllus by simplified economic process. It was subjected for various physicochemical parameters like color, colour changing point, chemical tests, IR spectral study. Ibuprofen sustained release tablets were prepared by using various formulation additives. Three atorvastatin loaded formulations(FA1-FA3) were prepared by using varying polymer ratios of 1:1, 1:3, 1:5 and other excipients like starch, talc, lactose. The formulations were evaluated for hardness, friability, weight variation, disintegration and in-vitro release study. On the basis of evaluation parameters formulation FA3 was found to be the best as It showed a t50% of 400 mins and t80% of more than 10 hours with weight variation of 3.8%, friability of 1.2%, hardness of 5 k...
Formulation development and evaluation of colon targeted oral drug delivery system of atorvastatin
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The aim of the present work was to develop and evaluate colon specific sustained release tablet using Atorvastatin, coating material and matrix forming polymers. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different ratio of polymers. Eudragit L100 and S100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. Drug and physical mixture were evaluated for incompatibility study by Fourier transform infrared spectroscopy (FTIR). Tablets were evaluated for micromeritic properties of granules, physical properties and drug content. All the batches of matrix tablet (ACD1-ACD5) were subjected for in-vitro dissolution in various simulated gastric fluids for suitability for c...
2016
E-mail: sanju1980dey@gmail.com The objective of the present study was to prepare solid dispersion (SD) and inclusion complexes of atorvastatin (ATV) using different hydrophilic carriers (polyethylene glycol (PEG 4000 and PEG 6000), polyvinyl pyrrolidone (PVP K30), and D-mannitol) and β-cyclodextrin (β-CD), respectively to improve the aqueous solubility and dissolution rate. Different drug: carrier ratios (1:1, 1:2, and 1:3) were used and their effects on the dissolution performance were studied. The physical state and drug-carrier interaction in solid state were analyzed by infrared spectroscopy, differential scanning calorimetry, and X-ray diffraction. The dissolution rate of ATV from tablets containing β-CD inclusion complex was compared with conventional tablets without β-CD. In vivo pharmacokinetic studies were performed on rabbits to compare the in vivo performance between tablets with or without inclusion complex. Improvement in the drug dissolution rate was observed in SDs an...