Implementation of sonication and feedback control strategies for targeted hyperthermia in prostate with a commercial MR-guided endorectal ultrasound ablation array (original) (raw)
Related papers
Journal of Therapeutic Ultrasound, 2018
Background: Hyperthermia therapy (HT) has shown to be an effective adjuvant to radiation, chemotherapy, and immunotherapy. In order to be safe and effective, delivery of HT requires maintenance of target tissue temperature within a narrow range (40-44°C) for 30-60 min, which necessitates conformal heat delivery and accurate temperature monitoring. The goal of this project was to develop an MR thermometry-guided hyperthermia delivery platform based upon the ExAblate prostate array that would achieve uniform stable heating over large volumes within the prostate, while allowing the user to precisely control the power deposition patterns and shape of the region of treatment (ROT). Methods: The HT platform incorporates an accelerated multi-slice real time MR thermometry pulse sequence and reconstruction pipeline. Temperature uniformity over a large contiguous area was achieved by multi-point temperature sampling with multi-focal feedback power control. The hyperthermia delivery system was based on an InSightec ExAblate 2100 prostate focused ultrasound ablation system, and HeartVista's RTHawk real-time MRI system integrated with a 3 T MRI scanner. The integrated system was evaluated in experiments with a tissue-mimicking phantom for prolonged exposures with a target temperature increase of 7°C from baseline. Results: Five various shapes of the region of treatment, defined on a 5 × 5 grid (35 × 35 mm, 11-25 focal spots per shape), were implemented to evaluate the performance of the system. MR temperature images, acquired after steady state was reached, showed different patterns of heating that closely matched the prescribed regions. Temperature uncertainty of the thermometry acquisition was 0.5°C. The time to reach the target temperature (2:58-7:44 min) depended on the chosen ROT shape and on the distance from transducer to focal plane. Pre-cooling with circulating water helped to reduce near-field heating. Conclusions: We have implemented a real-time MR thermometry-guided system for hyperthermia delivery within user-defined regions with the ExAblate prostate array and evaluated it in phantom experiments for different shapes and focal depths. Our results demonstrate the feasibility of using a commercially available endorectal FUS transducer to perform spatially-conformal hyperthermia therapy and could lead to a new set of exciting applications for these devices.
Biomedical Engineering Online, 2006
Background: Ultrasound induced hyperthermia is a useful adjuvant to radiation therapy in the treatment of prostate cancer. A uniform thermal dose (43°C for 30 minutes) is required within the targeted cancerous volume for effective therapy. This requires specific ultrasound phased array design and appropriate thermometry method. Inhomogeneous, acoustical, three-dimensional (3D) prostate models and economical computational methods provide necessary tools to predict the appropriate shape of hyperthermia phased arrays for better focusing. This research utilizes the k-space computational method and a 3D human prostate model to design an intracavitary ultrasound probe for hyperthermia treatment of prostate cancer. Evaluation of the probe includes ex vivo and in vivo controlled hyperthermia experiments using the noninvasive magnetic resonance imaging (MRI) thermometry.
Conformal heating using scanned 1-D phased array for external ultrasound hyperthermia
2001 IEEE Ultrasonics Symposium. Proceedings. An International Symposium (Cat. No.01CH37263), 2001
The feasibility of one-dimensional phased array transducer with mechanical scanning to produce a conformal heating for external ultrasound hyperthermia was evaluated. For the configuration of this system, numbers of focal spots were distributed within the target volume. To achieve the goal of conformal heating, an algorithm was introduced to calculate the power weighting for each field pattern to produce a heating volume conformal to the shape of the target volume. Simulation results showed that rather high cure rate in target volume with less damage rate in normal tissue can be obtained for target volumes with different shapes.
A cylindrical-section ultrasound phased-array applicator for hyperthermia cancer therapy
IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 1988
A new phased-array applicator geometry for deep localized hyperthermia is presented. The array consists of rectangular transducer elements forming a section of a cylinder that conforms to the body portals in the abdominal and pelvic regions. Focusing and scanning properties of the cylindrical-section array are investigated in homogeneous lossy media using appropriate computer simulations. The characteristic focus of this array is shown to be spatially limited in both transverse and longitudinal directions with intensity gain values suitable for deep hyperthermia applications. The ability of the cylindricalsection phased array to generate multiple foci using the field conjugation method is examined. The effect of the grating lobes on the power deposition pattern of the scanned field is shown to be minimal. Steadystate temperature distributions are simulated using a tbree-dimensional (3-D) thermal model of the normal tissue layers surrounding a tumor of typical volume. Finally, the advantages and the limitations of this array configuration are discussed.
2004
Of the different modalities to induce local hyperthermia, focused ultrasound is the only noninvasive technology available at the moment. In addition to the 3D localization of the target region, it has been shown that MRI can provide real-time thermometry and allows online, automatic control of temperature evolution of the focal point. Treatment of a large tissue volume (as compared to the focal spot size, i.e., the ultrasound wavelength) can be achieved rapidly by moving the focal point along an inside-out spiral trajectory. It has been shown previously that under linear conditions of energy deposition versus temperature, the spatial profile of the temperature within a large area can be controlled. In this study, a proportional, integral, and derivative (PID) spatial-and-temporal controller is described for the control of the temperature evolution within the target region under more variable conditions. The aim was to reach a predefined temperature profile after a few successive trajectories. Heat conduction in tissue is exploited to obtain a uniform temperature increase in a volume using discrete sonications without any waiting time. Input data sets consisted of 3D temperature maps provided online by a MR scanner. For each new trajectory, the controller recalculates the number of sonications per surface unit (spatial density of points describing the trajectory) and the applied power. Its performance was tested ex vivo and in vivo. Diameters of the target region ranged from 9 mm to 19 mm. Targeted temperature increase ranged from +8 degrees C to +18 degrees C. Spatiotemporal temperature control showed good stability and fast convergence, for both circular and elliptic ROIs.
Magnetic Resonance in Medicine, 2000
Temperature regulation in MR-guided focused ultrasound requires rapid MR temperature mapping and automatic feedback control of the ultrasound output. Here, a regulation method is proposed based on a physical model of local energy deposition and heat conduction. The real-time evaluation of local temperature gradients from temperature maps is an essential element of the control system. Each time a new image is available, ultrasound power is adjusted onthe-fly in order to obtain the desired evolution of the focal point temperature. In vitro and in vivo performance indicated fast and accurate control of temperature and a large tolerance of errors in initial estimates of ultrasound absorption and heat conduction. When using correct estimates for the physical parameters of the model, focal point temperature was controlled within the measurement noise limit. Initial errors in absorption and diffusion parameters are compensated for exponentially with a user-defined response time, which is suggested to be on the order of 10 sec. Magn Reson Med 43:342-347, 2000.
1992
This paper presents a new method which obtains ultrasound hyperthermia applicator phased-array element driving signals from a desired temperature distribution. The approach combines a technique which computes array element driving signals from focal point locations and intensities with a new technique which calculates focal point locations and power deposition values from temperature requirements. Temperature specifications appear here as upper and lower bounds within the tumor volume, and a focal point placement algorithm chooses focal patterns capable of achieving the temperature range objective. The linear algebraic structure of the method allows rapid calculation of both the phased-array driving signals and an approximate temperature field response. Computer simulations verify the method with a spherical section array (SSA) for a variety of temperature specifications and blood perfusion values. This scheme, which applies to any phased-array geometry, completes an essential step in both treatment planning and feedback for hyperthermia with ultrasound phased-array applicators.
Focused Array Hyperthermia Applicator: Theory and Experiment
IEEE Transactions on Biomedical Engineering, 2000
The design and analysis of a focused linear array at 2450 MHz for microwave hyperthermia research is described. The array, which was submerged in deionized water to reduce its size and to provide a better impedance match to a high dielectric medium representative of human tissues, consisted of four titanium dioxide loaded horn antennas with apertures of 2.0 x 1.4 cm and a feed network with weighted phase shifts, Power radiation pattern measurements were made in planes ranging from 7.6 to 10.2 cm from the array to determine the focusing characteristics and beam spot size. Due to high attenuation in the medium, planes beyond 10.2 cm were not considered. The half-power beamwidth (HPBW) measured at the focal point was approximately 1.3 cm. The measured patterns were found to be in close agreement with theoretical predictions. the array and the layer of tissue (c2). The distance between the plane of the antenna array and the surface of the tissue is d, while d2 is the distance from the surface of the tissue to the desired focal point or depth of the tumor.
IEEE Transactions on Biomedical Engineering, 2012
A system for the realtime generation and control of multiple-focus ultrasound phased-array heating patterns is presented. The system employs a 1-MHz, 64-element array and driving electronics capable of fine spatial and temporal control of the heating pattern. The driver is integrated with a realtime 2D temperature imaging system implemented on a commercial scanner. The coordinates of the temperature control points are defined on B-mode guidance images from the scanner, together with the temperature set points and controller parameters. The temperature at each point is controlled by an independent proportional, integral, and derivative (PID) controller that determines the focal intensity at that point. Optimal multiple-focus synthesis is applied to generate the desired heating pattern at the control points. The controller dynamically reallocates the power available among the foci from the shared power supply upon reaching the desired temperature at each control point. Furthermore, anti-windup compensation is implemented at each control point to improve the system dynamics. In vitro experiments in tissue-mimicking phantom demonstrate the robustness of the controllers for short (2-5 sec) and longer multiple-focus HIFU exposures. Thermocouple measurements in the vicinity of the control points confirm the dynamics of the temperature variations obtained through noninvasive feedback.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2006
Focus splitting by using sector-sectioned phased arrays is one of effective methods to increase the necrosed volume in single sonication and to reduce the total treatment time in large tumor treatment. However, the split focus contains less concentrated energy and severer focal beam distortion, which limits its usefulness in practical treatments. In this study, we proposed a new heating strategy by combining sonications of strongly-focused and split-focused patterns to increase the heating efficiency. Theoretical predictions and ex-vivo tissue experiments showed that thermal lesions can be enlarged in dimensions after applying the proposed strategy. This may provide a useful way to solve current obstacles in low heating efficiency of split-focus sonications that attempted to shorten the total treatment time in current clinical application.