Bilateral Lymphoblastic Lymphoma of Breast Mimicking Inflammatory Breast Cancer: A Case Report and Review of Literature (original) (raw)
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A case of primary bilateral breast lymphoma presenting with a painless mass in the left breast
Journal of Clinical and Investigative Surgery, 2021
Breast cancer is the most common cancer in women. Patients usually present with a rapidly progressed painless mass in the breast. The first pathological entity to be considered is breast cancer in case of newly developed painless mass, so that radiological and pathological evaluations must be performed. However, some systemic disorders; benign conditions like rheumatological diseases, and also systemic malignancies such as lymphoma, can mimic breast cancer by involving the breast. It is necessary to distinguish between such diseases through a correct diagnosis, because they have very different treatments and prognoses. We present a case diagnosed as bilateral primary breast lymphoma with a palpable mass in a single breast, its clinical and radiological characteristics. This case report suggests that systemic diseases should be considered in the differential diagnosis of breast diseases and breast masses, especially when there is bilaterally involvement, as discussed in this article.
Archives of Gynecology and Obstetrics, 2009
Non-Hodgkin lymphoma of the breast is a rare malignancy and present with almost equal frequency either as a primary or a secondary disease. Survival is poor in most cases of secondary breast lymphoma because of their advanced stage. We report a 35-year-old woman presenting with dyspnea as well as swelling, tenderness, and ruddiness in the left breast with non-cyclic pain for several months and maculopapular skin eruption in the same breast. Physical examination revealed fixed lymphadenopathies in both axillary regions. Radiologic evaluations (bilateral mammaograpy and ultrasonography) showed skin thickening in the left breast, asymmetrical densities in both breasts, and confirmed lymphadenopathies in the axillary regions. Excisional biopsies were performed to the left axillary lymph nodes and the breast skin eruptions. The histologic and immunohistochemical features were diagnosed as an ALK (−) anaplastic large cell lymphoma. A Computed Tomography examination was performed for staging the lymphoma and then chemotherapy was started. Thirty months after the diagnosis, the patient is still alive with disease. Because of the presence of systemic symptoms such as skin involvement and generalized lymphadenopathies (mediastinal, axillary or cervical), T cell lymphoma cases with breast involvement could mimic the clinical presentation of inflammatory breast carcinoma. Pathologic examination is needed for the correct diagnosis.
Bilateral Primary Breast Lymphoma: A Rare Case
thejournalofbreasthealth.com
Primary non Hodgkin's lymphoma of the breast is rare. Bilateral involvement of the breasts is even morerare. Lymphomas are divided into two groups: Hodgkin's Lymphoma and non Hodgkin's lymphoma. Diffuse large cell non Hodgkin's lymphoma is the most common type. A 56 year old female presented with masses in both breasts. An excisional biopsy was obtained from both tumoral masses. Histopathological assessment revealed diffuse large cell non Hodgkin's lymphoma and chemotherapy was started. Here we present the case of bilateral primary breast lymphoma while discussing clinical characteristics, treatment modalities and the outcomes.
Breast Lymphoma. Report of 2 Cases and Review of Literature
Breast Lymphoma. Report of 2 Cases and Review of Literature
Breast lymphoma is an uncommon lymphoma and rare type of breast cancer. Primary breast lymphoma represents 1% of all extranodal lymphomas and close to 0.7% of all lymphomas. Primary breast lymphoma can present as an aggressive disease with aggressive histology and mimics breast carcinoma in age distribution. It is usually unilateral. In pregnant and lactating females, primary breast lymphoma is typically bilateral. DLBCL is the most frequent histopathological subtype. Staging relies on physical exam, CT scan, or better FDG PET scan. Treatment follows guidelines and recommendations of lymphoma therapy. Chemothera-py using anthracycline based regimen is the preferred treatment. Radiotherapy may be used as part of the adjuvant regimen, or as single modality primary therapy for local only disease. CNS prophylaxis is indicated in aggressive histologies and higher stages. We present herein 2 cases of breast lymphoma. The first case in the peripartum and may have appeared during pregnancy and the second in a postmenopausal woman.
Disseminated high-grade malignant lymphoma involving both breasts
The Breast, 2002
S U M M A R Y . Primary or secondary involvement of the breast is a rare form of extranodal lymphoma. In this paper, we present a 36-year-old female patient admitted to the hospital with bilateral breast masses. Histological examination confirmed high-grade malignant lymphoma involving both breasts. r
OALib, 2020
Primary breast lymphoma (PBL) is considered a rare clinical entity, representing approximately 0.4% to 0.5% of all breast tumors. In this report, we present a case of Primary breast lymphoma in a 19-year-old woman complaining of a lump in the right breast and a nodule in the left breast. Breast imaging pointed towards PBL which was confirmed by the results of immunohistochemistry. The case was eventually diagnosed as non-Hodgkin's type B lymphoma. The management of PBL and carcinomas is completely different. The value of preoperative diagnosis should be emphasized, as the patient avoids unnecessary surgery and begins chemotherapy earlier.
Breast Lymphoma: A Report of 5 Cases and Literature Review
Breast lymphoma may occur as either a primary or a secondary lesion and the secondary form is more common than the primitive form. We report five cases of breast lymphoma who underwent multimodal breast imaging studies in our institute between March 2018 and June 2020, one was primary and the others were secondary. The multimodal imaging consisted of mammography, ultrasonography (US) and dynamic computed tomography (CT). The objective of this paper was to illustrate the multimodal imaging findings in the primary and secondary forms of breast lymphoma and to describe the key clinical and radiological findings that allow it to be distinguished from other breast malignancies.
A case of primary breast diffuse large B cell lymphoma
Tạp chí Nghiên cứu Y học, 2021
Primary breast diffuse large B-cell lymphoma (DLBCL) is a rare non-Hodgkin’s lymphoma with limited data. We here report a case of primary breast diffuse large B-cell lymphoma mimicking breast cancer. A 52-year-old woman had a painless mass in her right breast. Fine needle aspiration cytology and core biopsy were performed which suggested malignant features but could not confirm the specific subtype. Excisional biopsy then was conducted revealing non-Hodgkin lymphoma, which was subsequently confirmed with histopathology and diagnosed as diffuse large B-cell lymphoma (DLBCL). A chest computed tomography scan revealed a 3.5 cm sized breast mass with skin thickening and modest lymphadenopathy in the ipsilateral axilla. The patient received six courses of R-CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisolone plus rituximab) chemotherapy, then whole breast radiation (30Gy in 15 fractions). At 12 months of follow-up, the patient survives with no evidence of disease. No morbi...
Primary Non-Hodgkin’s Lymphoma of the bilateral Breast and review the literature
Journal of Medical Research and Health Sciences, 2020
Primary bilateral breast Non-Hodgkin’s lymphomas are the rare tumors found during the pregnancy and postpartum period. Diffuse large B-cell lymphoma (DLBCL) is the most common histological diagnosis. Lymphomas in breasts grow faster in pregnant or postpartum women especially, in those who are infected with Human Immunodeficiency Virus (HIV). Confirmation of diagnosis is usually delayed because of breasts’ extraordinary engorgement, hormonal changes during the pregnancy or lactation and most of the patients are diagnosed in advanced stages. Rapidly growing breast mass in HIV patients during the antenatal and postpartum period should undergo prompt investigations and early treatment if proven lymphoma.