Therapeutic prospects of microRNAs in cancer treatment through nanotechnology (original) (raw)

2017, Drug Delivery and Translational Research

Introduction-role of miRNAs in regulating disease MicroRNAs (miRNAs) were initially identified in Caenorhabditis elegans in 1993, as small non-coding RNAs, which modulate eukaryotic gene expression at posttranscriptional levels. Lee et al. first reported that the lin-4 gene was involved in larval development of Caenorhabditis elegans [1]. miRNAs play an important role in various physiological and pathological conditions including embryonic differentiation, viral infection, cardiac hypertrophy, hematopoiesis, and oncogenesis. miRNAs control a wide variety of cellular processes, such as proliferation, cell death, differentiation, motility, and invasiveness. [2, 3]. Different biological and physicochemical factors govern the effective delivery of miRNAs (Fig. 1). Delivery can be improved through various approaches such as [4, 5]

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