RAG Represents a Widespread Threat to the Lymphocyte Genome (original) (raw)

The RAG2 C-terminus and ATM protect genome integrity by controlling antigen receptor gene cleavage

Kluger, Kluger

Nature Communications, 2013

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The “Dispensable” Portion of RAG2 Is Necessary for Efficient V-to-DJ Rearrangement during B and T Cell Development

Garnett Kelsoe

Immunity, 2002

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N-terminal truncated human RAG1 proteins can direct T-cell receptor but not immunoglobulin gene rearrangements

NiCo Nicole

Blood, 2000

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The RAG2 C terminus suppresses genomic instability and lymphomagenesis

Jane Skok, L. Deriano

Nature, 2011

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Mechanistic Basis for RAG Discrimination between Recombination Sites and the Off-Target Sites of Human Lymphomas

Michael Lieber

Molecular and Cellular Biology, 2012

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Mechanisms controlling expression of the RAG locus during lymphocyte development

Mark Schlissel

Current Opinion in Immunology, 2009

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Signaling pathways regulating RAG expression in B lymphocytes

Sophie Hillion

Autoimmunity Reviews, 2009

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Early death and severe lymphopenia caused by ubiquitous expression of the Rag1 and Rag2 genes in mice

Jocelyne Demengeot

European Journal of Immunology, 2001

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A dimer of the lymphoid protein RAG1 recognizes the recombination signal sequence and the complex stably incorporates the high mobility group protein HMG2

Leon Ptaszek

Nucleic Acids Research, 1999

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The RAG1/RAG2 Complex Constitutes a 3′ Flap Endonuclease

Paolo Vezzoni

Molecular Cell, 1999

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A PHD finger motif in the C terminus of RAG2 modulates recombination activity

Dmitri Ivanov

Journal of Biological …, 2005

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Leaky severe combined immunodeficiency and aberrant DNA rearrangements due to a hypomorphic RAG1 mutation

David Schatz

Blood, 2009

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The RAG1 Ubiquitin Ligase Domain Enhances Assembly and Selection of T Cell Receptor Genes to Restrain the Autoimmune Hazard of Generating T Cell Receptor Diversity

Jessica Jones

2021

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A Zinc-binding Domain Involved in the Dimerization of RAG1

Donald Engelman

Journal of Molecular Biology, 1996

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Hypomorphic Rag1 mutations alter the pre-immune repertoire at early stages of lymphoid development

Olle Kämpe

Blood, 2018

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Central and Peripheral RAG Protein Re-expression: Underestimate Mechanisms of Tolerance

Sophie Hillion

Scandinavian Journal of Immunology, 2006

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Characterization of T and B cell repertoire diversity in patients with RAG deficiency

Shereen Reda

Science Immunology, 2016

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RAG-1 and Ly6D Independently Reflect Progression in the B Lymphoid Lineage

Kay Medina

PLoS ONE, 2013

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RAG2 is regulated differentially in B and T cells by elements 5' of the promoter

Roger Ferrini

Proceedings of the National Academy of Sciences, 1999

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The immunophenotypic and immunogenotypic B-cell differentiation arrest in bone marrow of RAG-deficient SCID patients corresponds to residual recombination activities of mutated RAG proteins

JACQUES JM VAN DONGEN

Blood, 2002

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Autoubiquitylation of the V(D)J recombinase protein RAG1

Jessica Jones

Proceedings of the National Academy of Sciences, 2003

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Combinatorial regulation of the murine RAG2 promoter by Sp1 and distinct lymphocyte-specific transcription factors

Gustavo Miranda

Molecular Immunology, 2002

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RAG2: GFP knockin mice reveal novel aspects of RAG2 expression in primary and peripheral lymphoid tissues

Roger Ferrini

Immunity, 1999

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A recombinase diversified: new functions of the RAG proteins

V L Brandt

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RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci

Jacques Ghysdael

Nature Immunology, 2009

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Andrew Stubbs, Anton Langerak

Journal of Allergy and Clinical Immunology, 2014

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RAG Represents a Widespread Threat to the Lymphocyte Genome (original) (raw)

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