(A) Expression of GFP in liver sections at several times after infection of CYP2D6 mice with Ad-GFP (original) (raw)

2011

Abstract

Bars, 50 μm. (B) Serum levels of ALT and AST in humanized CYP2D6 and wild-type FVB/N mice infected with Ad-2D6 or Ad-GFP at several times after infection. Note that elevations in serum ALT and AST were transient and not persistent. Statistical evaluation ( test) revealed no significant differences in AST and ALT augmentation curves over time between Ad-2D6– and Ad-GFP–infected mice (FVB, P = 0.7 [ALT] and 0.79 [AST]; CYP2D6, P = 0.5 [ALT] and 0.13 [AST]) and between FVB/N and CYP2D6 mice (Ad-2D6, P = 0.64 [ALT] and 0.59 [AST]; Ad-GFP, P = 0.31 [ALT] and 0.82 [AST]). (C) Serum levels of AP in humanized CYP2D6 and wild-type FVB/N mice infected with Ad-2D6 or Ad-GFP at several times after infection ( = 5 per group). Transient AP elevation was detected in CYP2D6 and FVB/N mice at weeks 1 and 2 after infection with Ad-2D6 but not Ad-GFP. Statistical evaluation ( test) revealed significant differences in serum AP compared with preinfection levels (week 1, P = 0.035 [FVB/N Ad-2D6]; week 2, P = 0.044 [FVB/N Ad-2D6] 0.029 [CYP2D6 Ad-2D6]) and between Ad-2D6– and Ad-GFP–infected mice (week 1, P = 0.03 [FVB] and 0.063 [CYP2D6]; week 2, P = 0.055 [FVB] and 0.029 [CYP2D6]). Data are mean ± SD.<b>Copyright information:</b>Taken from "Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection"The Journal of Experimental Medicine 2008;205(6):1409-1422.Published online 9 Jun 2008PMCID:PMC2413037.

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