Embryo implantation rates in oocyte donation: a prospective comparison of tubal versus uterine transfers (original) (raw)
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Uterine versus Tubal Embryo Transfer in the Human
Annals of the New York Academy of Sciences, 1991
In the last twelve years, the field of infertility treatment has undergone a revolution due to the appearance of assisted reproductive technologies. The two techniques responsible for these drastic changes in the care of the infertile couple have been in vitro fertilization and embryo transfer (IVF-ET) and gamete intrafallopian transfer (GIFT), introduced in 1978 and 1984, respective1y.'r2 Originally, IVF-ET and GIFT were developed in order to assist infertile couples with tubal disorders and unexplained or idiopathic infertility, respectively.
Journal of Experimental and Clinical Medicine
This research aimed to show the role of the number of transferred embryos on pregnancy outcomes of the oocyte donation cycles (ODC). This retrospective cohort study included 122 ODCs performed at a private in vitro fertilization (IVF) center between 2020 June - 2021 January. Cases with severe male infertility, tuboperitoneal, and endometrial factors were not included in the study. The median (interquartile range) recipient age was 43 (30–54) years. ODC results revealed that 10.7% of the cases were negative, 4.9% were biochemical pregnancies, and 84.4% were clinical pregnancies. Pregnancy outcomes were checked; miscarriage, preterm, and term delivery rates were 5.7%, 3.9%, and 90.4%, respectively. The rate of recipients for the younger than 40 years was 32%, between the 40–44 years was 27%, and between 45–54 years was 41% respectively. Statistically significant difference was not observed between age groups in terms of endometrial thickness (p = 0.059), number of transferred embryos ...
Human Reproduction, 1996
Synchronization of the availability of good quality oocytes from donors and adequate endometrial maturation of recipients are very important for the success of an oocyte donation programme. A flexible protocol for the endometrial preparation of recipients is important in timing embryo transfer between days 17 and 19 of the cycle ('window of receptivity'). The purpose of this study was to evaluate the effect of the length of oestradiol administration to recipients on pregnancy outcome. Oestrogen administration was 8 mg/day, but its length varied prospectively from 6 to 27 days, followed by the addition of progesterone (100 mg daily Lm.) for 2-4 days according to the availability of good quality oocytes. Pregnancy outcome was evaluated regardless of age, indication for oocyte donation or number of embryos transferred per patient The pregnancy rate per cycle was comparable when oestradiol was administered from 6 to 11 days before progesterone addition, while it dropped significantly thereafter. The variation in progesterone administration did not affect pregnancy outcome. These findings provide us with a greater flexibility by allowing us to vary oestradiol administration to recipients from 6 to 11 days prior to progesterone, reducing considerably, therefore, the need to cancel embryo transfer because of oocyte unavailability. Thus we can arrange to transfer embryos between days 17 and 19 of the recipient's cycle so as to obtain the best possible clinical outcome.
Taiwanese journal of obstetrics & gynecology, 2006
To compare the results of embryo transfer into the uterus (ET) performed on day 3 vs. tubal embryo transfer (TET) on day 2 in couples diagnosed with male factor infertility. We collected data from 34 and 110 patients who underwent intracytoplasmic sperm injection (ICSI) followed by either TET on day 2 or ET on day 3 (January 2001-June 2005), respectively. All couples were diagnosed with male factor infertility; there were no tubal or uterine factors, diminished ovarian reserve, pelvic adhesions, history of polycystic ovary syndrome or previous ovarian surgery. The clinical pregnancy rates of day 2 TET and day 3 ET following ICSI were 64.71% and 57.27% (p > 0.05), respectively. The corresponding implantation rates were 35.47% and 29.58% (p > 0.05), respectively. The implantation and clinical pregnancy rates of ET on the 3rd day following ICSI were similar to the rates obtained with TET 2 days after ICSI. Therefore, ET performed 3 days after ICSI should be the first choice for c...
Asia-Oceania Journal of Obstetrics and Gynaecology, 2010
Forty-six couples with various causes of infertility were treated by tubal embryo transfer. Oocyte retrievals were carried out under ultrasound guidance transvaginally and embryos were transferred 48 hours later by laparoscopy into fallopian tubes. Totally 52 cycles were stimulated and 45 retrievals were performed with an average of 8.1 oocytes per retrieval. The average fertilization rate was 54.8%. The implantation rate was 23.8% and the pregnancy rate was 53.5% per transfer. The pregnancy rate per transfer was comparable whether 3 or 4 embryos were transferred. Nine (39.1%) of the 23 pregnancies had multiple pregnancies. Six cases (26.1%) aborted in the first trimester and the remaining 17 were ongoing or term delivery.
Fertility and Sterility, 2006
To compare the outcome of day 2 and day 3 embryo transfers in women demonstrating poor ovarian response. Prospective randomized clinical trial. Private assisted reproductive technology center. Two hundred eighty-one women demonstrating poor ovarian response to controlled ovarian hyperstimulation. Women who were poor responders were randomly allocated to day 2 or day 3 embryo transfer following oocyte retrieval. Implantation rates and pregnancy rates per oocyte retrieval and embryo transfer. The clinical pregnancy rates per oocyte retrieval (37.2% vs. 21.4%, respectively; P<.05) and per embryo transfer (38.9% vs. 24.1%, respectively; P<.05) were significantly higher in the day 2 embryo transfer group compared with day 3. On the other hand, implantation rates were not different between groups (23.9% vs. 17.2%, respectively; P=.08). Our results demonstrated that transfering embryos on day 2 could provide an alternative to the management of poor responder patients.
Volume 18, Issue 1 , January , 2024
Background: Induced endometrial injury is a technique described that have positive impact on implantation. The aim of this study was to investigate whether hysteroscopic endometrial fundal incision (EFI) in oocyte recipients before embryo transfer increases pregnancy and live birth rates or not. Materials and Methods: A prospective study was conducted between 2014 and 2019 at an in vitro fertilization (IVF) unit in Greece. As part of the protocol, hysteroscopy and EFI were offered to all the egg recipients and the outcomes compared with those from an older cohort from the same Unit not undergoing hysteroscopy. Results: In total, 332 egg recipients participated in the study; 114 of them underwent EFI prior to embryo transfer. Both groups were similar in terms of age, years of infertility, duration of hormone replacement treatment (HRT) and number of blastocysts transferred. In the EFI group, minor anomalies were detected and treated in 6.1% (n=7) of the participants. Moreover, pregnancy test was positive in 73.7% of the women in the hysteroscopy group compared to 57.8% in the nonhysteroscopy group (P=0.004). Live birth rate was also higher (56.1 vs. 42.2%, P=0.016) in the EFI group compared to the non-hysteroscopy one. Conclusion: Apart from the obvious benefit of recognizing obscured anomalies, requiring surgical correction, it appears that in oocyte recipients prior to embryo transfer, EFI might improve uterine receptivity and reproductive outcomes.