DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease (original) (raw)

DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid -peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer’s disease

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Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease

Irina Petrushina

Molecular Therapy, 2017

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Immunogenicity of DNA- and recombinant protein-based Alzheimer Disease epitope vaccines

Kanitha Patarakul

Human Vaccines & Immunotherapeutics, 2014

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Alzheimer's disease: is a vaccine possible?

Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.], 2014

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Developing novel immunogens for a safe and effective Alzheimer's disease vaccine

Progress in Brain Research, 2009

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Aβ vaccination of a genetic model of Alzheimer's disease

International Congress Series, 2003

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Immunization with a new DNA vaccine for Alzheimer's disease elicited Th2 immune response in BALB/c mice by in vivo electroporation

2011

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Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer?s disease

Journal of Molecular Medicine, 2004

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Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from beta-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide

Michael Agadjanyan

Journal of immunology (Baltimore, Md. : 1950), 2005

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Successful adjuvant-free vaccination of BALB/c mice with mutated amyloid β peptides

BMC Neuroscience, 2008

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Prototype Alzheimer's Disease Vaccine Using the Immunodominant B Cell Epitope from -Amyloid and Promiscuous T Cell Epitope Pan HLA DR-Binding Peptide

Irina Petrushina

The Journal of Immunology, 2005

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Immune shaping and the development of Alzheimer's disease vaccines

Howard Federoff

2005

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A Comparative Evaluation of a Novel Vaccine in APP/PS1 Mouse Models of Alzheimer’s Disease

Madepalli Lakshmana, Carmen Vigo

BioMed Research International, 2015

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Thomas Wisniewski

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Refinement of a DNA based Alzheimer disease epitope vaccine in rabbits

Irina Petrushina

2013

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MER5101, a novel Aβ1-15:DT conjugate vaccine, generates a robust anti-Aβ antibody response and attenuates Aβ pathology and cognitive deficits in APPswe/PS1ΔE9 transgenic mice

The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013

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Rejecting the Alzheimer's disease vaccine development for the wrong reasons

Drug Discovery Today, 2017

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DNA prime–protein boost increased the titer, avidity and persistence of anti-Aβ antibodies in wild-type mice

Irina Petrushina

Gene Therapy, 2010

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Amyloid-β Immunotherapy for Alzheimers Disease

Cns & Neurological Disorders-drug Targets, 2010

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Low Concentrations of Anti-Aβ Antibodies Generated in Tg2576 Mice by DNA Epitope Vaccine Fused with 3C3d Molecular Adjuvant Do Not Affect AD Pathology

Human Gene Therapy, 2010

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Development of Alzheimer’s Disease Vaccines: a Perspective

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Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

Nature Neuroscience, 2002

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The generation and characterization of potentially therapeutic Aβ antibodies in mice: differences according to strain and immunization protocol

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Promising Results from Alzheimer’s Disease Passive Immunotherapy Support the Development of a Preventive Vaccine

Research, 2019

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An Immunomodulatory Therapeutic Vaccine Targeting Oligomeric Amyloid-β1

Journal of Alzheimer's Disease, 2020

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Vaccine Development to Treat Alzheimer’s Disease Neuropathology in APP/PS1 Transgenic Mice

International Journal of Alzheimer's Disease, 2012

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Alzheimer's Disease Peptide Epitope Vaccine Reduces Insoluble But Not Soluble/Oligomeric A Species in Amyloid Precursor Protein Transgenic Mice

Irina Petrushina, Hayk Davtyan, Grigor Mamikonyan

Journal of Neuroscience, 2007

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Novel Aβ peptide immunogens modulate plaque pathology and inflammation in a murine model of Alzheimer's disease

Maria Isabel Burgos Fonseca

2005

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Rationale for the development of an Alzheimer’s disease vaccine

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Amyloid-β Immunotherapy on Alzheimer disease: Prevention and Therapeutic Target

Opeyemi Adeloye

Journal of dermatology research and review, 2020

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A novel recombinant adeno-associated virus vaccine reduces behavioral impairment and β-amyloid plaques in a mouse model of Alzheimer's disease

Shibin Fazil Ma

Neurobiology of Disease, 2003

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Aβ immunotherapy for Alzheimer's disease: where are we?

Sandra Villegas

Neurodegenerative Disease Management, 2016

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