Five‐year results of a prospective, randomized, controlled study evaluating treatment of intra‐bony defects with a natural bone mineral and GTR (original) (raw)

Background: Treatment with a natural bone mineral (NBM) and a guided tissue regeneration (GTR) has been shown to promote periodontal regeneration. However, until now there are only very limited data on the long‐term clinical results following this regenerative technique.Aim: To present the 5‐year results of a prospective, randomized, controlled clinical study evaluating the treatment of deep intra‐bony defects either with open flap debridement (OFD) and a combination of an NBM and GTR (test) or OFD alone (control).Methods: Nineteen patients diagnosed with advanced chronic periodontitis, and each of whom displayed one intra‐bony defect, received randomly the test or the control treatment. Results were evaluated at baseline, at 1 and at 5 years following therapy.Results: No statistically significant differences in any of the investigated parameters were observed at baseline between the two groups. At 1 year after therapy, the test group showed a reduction in mean probing depth (PD) fr...