Five‐year results of a prospective, randomized, controlled study evaluating treatment of intra‐bony defects with a natural bone mineral and GTR (original) (raw)
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Journal of Clinical Periodontology, 2016
AimCompare the long‐term outcomes and costs of three treatment modalities in intra‐bony defects.Materials and MethodsForty‐five intra‐bony defects in 45 patients had been randomly allocated to receive: modified papilla preservation technique with titanium‐reinforced expanded‐polytetrafluoroethylene (ePTFE) membranes (MPPT Tit, N = 15); access flap with expanded‐PTFE membranes (Flap‐ePTFE, N = 15) and access flap alone (Flap, N = 15). Supportive periodontal care (SPC) was provided monthly for 1 year, then every 3 months for 20 years. Periodontal therapy was delivered to sites showing recurrences.ResultsForty‐one patients complied with SPC. Four subjects were lost to follow‐up. Clinical attachment‐level differences between 1 and 20 years were −0.1 ± 0.3 mm (p = 0.58) in the MPPT Tit; −0.5 ± 0.1 mm (p = 0.003) in the Flap‐ePTFE and −1.7 ± 0.4 mm (p < 0.001) in the Flap. At 20 years, sites treated with Flap showed greater attachment loss compared to MPPT Tit (1.4 ± 0.4 mm; p = 0.008)...
Brazilian Dental Journal, 2013
Intrabony periodontal defects present a particular treatment problem, especially in patients with generalized aggressive periodontitis (G-AgP). Regenerative procedures have been indicated for this clinical situation. The aim of this study was to compare treatment outcomes of intrabony periodontal defects with either anorganic bone matrix/cell binding peptide (ABM/P-15) or guided tissue regeneration (GTR) in patients with G-AgP. Fifteen patients, with two intrabony defects ≥3 mm deep, were selected. Patients were randomly allocated to be treated with ABM/P-15 or GTR. At baseline and at 3 and 6 months after surgery, clinical and radiographic parameters and IL-1β and IL-6 gingival fluid concentrations were recorded. There was a significant probing pocket depth reduction (p<0.001) for both groups (2.27 ± 0.96 mm for ABM/P-15 group and 2.57 ± 1.06 mm for GTR group). Clinical attachment level gain (1.87 ± 0.94 mm for ABM/P-15 group and 2.09 ± 0.88 mm for GTR group) was also observed. T...
Annals of periodontology / the American Academy of Periodontology, 2003
Many clinical studies have demonstrated that guided tissue regeneration (GTR) is a successful treatment modality of periodontal reconstructive surgery and it has become an accepted procedure in most periodontal practices. The purpose of this structured review was to assess the efficacy of guided tissue regeneration (GTR) procedures in patients with periodontal osseous defects compared with surgical controls on clinical, radiographic, adverse, and patient-centered outcomes. It extends the scope of previous GTR systematic reviews, which were limited to randomized controlled studies, by the scope of outcome measures examined, and the duration of the study. In patients with periodontal osseous defects, what is the effect of physical barriers compared with surgical controls on clinical, radiographic, adverse, and patient-centered outcomes? An electronic search of the Cochrane Oral Health Group Trials Register and MEDLINE databases was performed. Manual searching of journals included Jour...
Dental Research Journal, 2015
Background: Bone loss is one of the hallmarks of periodontitis. Hence, a major focus of research into periodontal regeneration has concentrated on the initiation of Osteogenesis. Osteoinduction requires the differentiation of mesenchymal cells into osteoblasts with subsequent formation of new bone. The present study has been carried out to evaluate periodontal bone regeneration in intrabony defects using osteostimulative oleaginous calcium hydroxide suspension Osteora ® (Metacura, Germany) in combination with osteoconductive bone graft Ossifi ™ (Equinox Medical Technologies, Holland). Materials and Methods: A total of 22 sites in patients within the age range of 25-50 years, with intrabony defects were selected and divided into two groups (Group A and Group B) by using the split-mouth design technique. All the selected sites were assessed with the clinical parameters such as-Plaque Index, Gingival Index, Sulcus Bleeding Index, Periodontal Probing Depth, Clinical Attachment Level, Gingival Recession and radiographic parameter to assess the amount of Defect Fill. Mann-Whitey U-test and Wilcoxon Signed Rank Test has been used to fi nd the signifi cance of study parameters on continuous scale for the comparison between the mesial and distal bone levels. P < 0.05 was considered to be statistically signifi cant. Results: Osteora ® in combination with osteoconductive Ossifi ™ showed better regenerative potential and more signifi cant amount of bone fi ll in periodontal intrabony defects than when Ossifi ™ was used alone (P = 0.039). Conclusion: Osteora ® can be used as an adjunct to osteoconductive bone grafts, as an osteostimulating agent in the treatment of periodontal intrabony defects.
Aim: To compare the contribution of combined guided tissue regeneration and deproteinated bovine bone (EnterOss) and guided tissue regeneration alone to the outcomes of the treatment of infrabony defects. Materials and Methods: A total of sixteen patients of both sexes satisfying the criteria of chronic periodontitis and each of whom displayed one infrabony defect were randomly assigned to two groups, i.e. either treated with EnterOss and guided tissue regeneration (GTR) (group A) or with (GTR) alone (group B), in this parallel-arm study. The soft tissue and hard tissue measurements, including probing pocket depth (PD), clinical attachment level (CAL), and bone mineral density were recorded at baseline and 3,6 and 12 months after surgery. The differences with a P < 0.05 were considered significant. Results: Results showed that the combined group showed significant difference when compared with GTR alone, in relation to the degree of periodontal pocket, clinical attachment loss, and bone density. While in relation to Plaque and Gingival indices there is no significant difference between the two groups. Conclusion: The findings of this study suggest that, combination of deproteinated bovine bone and biocollagen membrane could be considered as an option in the treatment of infrabony defects. GTR alone gives acceptable clinical results in the treatment of infrabony defects. Combination of deproteinated bovine bone and biocollagen membrane resulted in significant clinical results in the treatment of infrabony defects.