The Temporal Evolution of Histological Abnormalities in Microscopic Colitis (original) (raw)
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Microscopic colitis: A common and an easily overlooked cause of chronic diarrhoea
European Journal of Internal Medicine, 2008
Microscopic colitis, comprising collagenous colitis and lymphocytic colitis, is characterised clinically by chronic watery diarrhoea, a macroscopically normal colonic mucosa where diagnostic histopathological features are seen on microscopic examination. The annual incidence of each disorder is 4–6/100,000 inhabitants, with a peak incidence in 60–70 year old individuals and a noticeable female predominance in collagenous colitis. The aetiology is unknown. Abdominal pain,
Afro-Egyptian Journal of Infectious and Endemic Diseases (Online), 2022
Background and study aim: Microscopic colitis is an increasingly recognized cause of chronic watery nonbloody diarrhea. The diagnosis of microscopic colitis is mainly based on pathological examination of colonic biopsy from patients with chronic diarrhea and apparently normal colonoscopy examination. This study aimed at estimating frequency of microscopic colitis among patients with chronic watery non-bloody diarrhea and determining the role of some risk factors for its occurrence. Patients and Methods: This study included 60 patients with chronic watery non-bloody diarrhea. Colonoscopy examination was done for all patients and biopsy was taken for histopathology. All patients also evaluated by stool analysis, complete blood count, liver functions, kidney functions, thyroid functions, glycosylated hemoglobin, tissue transglutaminase and pelviabdominal ultrasound. Results: Microscopic colitis was diagnosed in 13 patients with 9 patients having lymphocytic colitis and 4 patients having collagenous colitis. The mean age of patients diagnosed with MC was about 45.7 ± 7.78 years and most of them were females (69.2 %). Patients with microscopic colitis suffered from diarrhea for longer durations. Microscopic colitis was more significant in patients with history of proton pump inhibitors and non-steroidal anti-inflammatory drugs use. Conclusion: Prevalence of microscopic colitis among studied patients was about 21.7% (15% lymphocytic colitis and 6.7% collagenous colitis). microscopic colitis was more common among females .
Microscopic Colitis and Colorectal Neoplastic Lesion Rate in Chronic Nonbloody Diarrhea
Inflammatory Bowel Diseases, 2014
Background: Lymphocytic and collagenous colitis are emerging as common findings in subjects undergoing colonoscopy for chronic non-bloody diarrhea (CNBD). Data concerning microscopic colitis (MC) are still limited and affected by controversial epidemiological evidences. Recent converging lines of evidence suggest that MC correlates a lower risk of colorectal neoplasia. Accordingly, we prospectively assessed MC prevalence in a multicenter cohort of subjects submitted to colonoscopy for CNBD, thereby defining whether MC influences the risk of colorectal neoplasia.
Distribution of histopathological features along the colon in microscopic colitis
International Journal of Colorectal Disease, 2020
Purpose The diagnosis microscopic colitis (MC) consisting of collagenous colitis (CC) and lymphocytic colitis (LC) relies on histological assessment of mucosal biopsies from the colon. The optimal biopsy strategy for reliable diagnosis of MC is controversial. The aim of this study was to evaluate the distribution of histopathological features of MC throughout the colon. Methods Mucosal biopsies from multiple colonic segments of patients with MC who participated in one of the three prospective European multicenter trials were analyzed. Histological slides were stained with hematoxylin-and-eosin, a connective tissue stain, and CD3 in selected cases. Results In total, 255 patients were included, 199 and 56 patients with CC and LC, respectively. Both groups exhibited a gradient with more pronounced inflammation in the lamina propria in the proximal colon compared with the distal colon. Similarly, the thickness of the subepithelial collagenous band in CC showed a gradient with higher values in the proximal colon. The mean number of intraepithelial lymphocytes was > 20 in all colonic segments in patients within both subgroups. Biopsies from 86 to 94% of individual segments were diagnostic, rectum excluded. Biopsies from non-diagnostic segments often showed features of another subgroup of MC. Conclusion Conclusively, although the severity of the histological changes in MC differed in the colonic mucosa, the minimum criteria required for the diagnosis were present in the random biopsies from the majority of segments. Thus, our findings show MC to be a pancolitis, rectum excluded, questioning previously proclaimed patchiness throughout the colon.
BMC Research Notes, 2014
Chronic non-bloody diarrhoea affects up to 5% of the population. Microscopic colitis is one of the most common causes, encompassing the subtypes collagenous colitis and lymphocytic colitis. The diagnosis of microscopic colitis is made by histological examination of colonic mucosal biopsy specimens. The aim of this investigation was to determine whether laboratory parameters or questions about disease history or concomitant disease could be helpful in discriminating patients with MC from those with a histologically normal colonic mucosa. Patients admitted for colonoscopy because of chronic non-bloody diarrhoea (>2 loose stools for >3 weeks) at endoscopy units in Malmö during 2007 and 2009, were enrolled. A total number of 78 patients were included (60 women, 18 men, median age 59, IQR 45-69 years). Out of these 78, 15 patients (19%) had microscopic colitis (CC; n = 10, LC; n = 5). MC was especially prevalent in patients above the age of 50 (25%). No differences were found between those with normal histology and MC in laboratory analyses (inflammatory and liver parameters). Neither were differences shown in questions regarding symptoms, environmental factors or concomitant diseases except for an association with celiac disease (p = 0.019) and a trend maybe indicating an inverse association with appendectomy (p = 0.057). Microscopic colitis is associated with female gender, celiac disease and consumption of NSAIDs. Trends were observed indicating that age above 50 years, acute onset and absence of appendectomy may be associated with MC. No associations were observed with other symptoms, calprotectin levels or liver parameters.
Advances in knowledge on microscopic colitis: From bench to bedside
Revista española de enfermedades digestivas : organo oficial de la Sociedad Española de Patología Digestiva, 2015
Microscopic colitis (MC) is a general term that describes a family of chronic inflammatory bowel diseases, including lymphocytic colitis (LC) and collagenous colitis (CC). The two forms are characterized by chronic watery diarrhea with normal or near normal endoscopic colonic appearance and specific histopathological abnormalities.Data from recent epidemiological studies reported the diagnosis of MC from several different regions in the world, providing that it can be a worldwide condition. The etiopathogenesis of MC still remains unknown but it is generally accepted that MC is a multifactorial disease, probably secondary to an abnormal immune reaction in predisposed individuals, triggered by different luminal factors (infections, drugs, autoimmunity and/or bile acids). Furthermore, some studies show that the epithelial barrier function in the colonic mucosa of MC patients is also impaired. Several mucosal factors of intestinal inflammation have been studied in MC, postulating that ...