Gastrik Intestinal Metaplazi Sıklığı ve Helikobakter Pilori ile İlişkisinin Belirlenmesi (original) (raw)
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2013
According to the Lauren's classification, two subtypes of GC can be distinguished basing on their different histology: the intestinal-type adenocarcinoma and the diffuse-type GC Lastraioli., 2012). The accepted model for the development of gastric adenocarcinoma of the intestinal type consists of the following precancerous steps: non-atrophic gastritis, multifocal atrophic gastritis, intestinal metaplasia (first Abstract Background: It is generally accepted that gastric carcinomas are preceded by a sequential multistage process that includes chronic gastritis, gastric atrophy, usually with intestinal metaplasia (IM), and dysplasia.
2017
Gastric cancer (GC) remains the second most leading cause of cancer-related deaths and ranks 4th in cancer incidence worldwide [1,2]. Incidence rates and presentation of gastric cancer show, however, marked regional differences, European countries tend to have a low incidence [3]. In contrast, in Iran for instance stomach cancer together with breast cancerhas the highest incidence and highest mortality of all types of oncological disease in this country [4]. In contrast, gastric cancer has a low prevalence in subSaharan Africa with the lowest incidence rates in Western Africa[5]. Thus, gastric cancer is constitutes a global health issue, but presentation is markedly different in various parts of the world, raising questions as to whether screening strategies should to be tailored according to geography. Appropriate screening is important as the prognosis of gastric cancer varies dramatically according to disease stage. The 5-year survival rate for advanced gastric cancer is less tha...
MetaplasiaCo-Occurrence of Helicobacter Pylori and Intestinal Metaplasia in Patients with Dyspepsia
Aim: Helicobacter pylori (HP) is a common gram negative bacteria associ-ated with peptic ulcer disease and malignancy. In this study we evaluated the co-occurrence of helicobacter pylori and intestinal metaplasia (IM) in pa-tients with dyspepsia. Material and Method: We retrospectively evaluated the gastroscopy and antral biopsy results of patients that were admitted to Siverek Government Hospital general surgery outpatient clinic with dys-pepsia between November 2013 and January 2015. Pathology samples were investigated with giemsa for HP and with PAS-AB for intestinal metaplasia. Results: We evaluated 682 patients (304 men, 378 women) with a mean age of 38.22 ±14.64 years (range 18-88 years). We diagnosed 555 (81.4%) with antral gastritis, 81 (11.9%) with pangastritis, and 6 (0.9%) with ulcero-vegetant tumoral lesion. Based on pathology we diagnosed 469 (69.6%) with chronic gastritis, 201 (29.5%) with inactive chronic gastritis, and 6 (0.9%) with adenocarcinoma. HP was detected in 475 (69.6%) patients, intestinal metaplasia was detected in 56 (8.2%) patients, and atrophy was seen in 11 (1.6%) patients. HP was detected in 4 (66.6%) of the 6 patients with adeno-carcinoma. In 48 patients with HP, intestinal metaplasia was also found. In 8 patients with intestinal metaplasia, HP was negative. Co-occurrence of HP and intestinal metaplasia was statistically significant (p: 0.006). Discussion: HP promotes intestinal metaplasia. The prevention and treatment of HP pre-vents precancerous lesions. In particular, patients with dyspepsia resistant to medical treatment should be examined carefully in general surgery practice
British journal of cancer, 1998
Helicobacter pylori (H. pylori) infection and intestinal metaplasia (IM) are each associated with an increased risk of gastric cancer (GC). To explore further the influences of H. pylori and IM on GC, H. pylori and subtypes of IM were evaluated in 135 sex and age-matched case and control pairs. Odds ratios (ORs) with 95% confidence intervals of developing GC were calculated for each risk factor using multiple logistic regression analysis. ORs for H. pylori infection and IM were 2.43 (1.29-4.65) and 4.59 (2.58-8.16), respectively, and those for different IM subtypes gave values of 0.82 (0.28-2.36) for type I, 2.03 (0.95-4.34) for type II and 39.75 (14.34-110.2) for type III. Stratification analysis by histological subtype and stage of GC showed a particularly high OR for IM in intestinal type (12.8, 4.73-34.83) and early GC (6.40, 2.25-18.18). Our data indicate that both H. pylori and IM are related to GC risk. Type III IM is a more specific marker of premalignancy, with relevance, i...
Co-Occurrence of Helicobacter Pylori and Intestinal Metaplasia in Patients with Dyspepsia
Annals of Clinical and Analytical Medicine, 2017
Helikobakter pilori (HP) toplumda yaygın olarak görülen, peptik ülser hastalığı ve malignitelerle ilişkili gram negatif bir bakteridir. Dispeptik şikâyetlerle başvuran hastalara yapılan endoskopik biyopsi sonucu HP sıklığı ve intestinal metaplazi birlikteliği incelenmiştir. Gereç ve Yöntem: Siverek Devlet Hastanesi Genel Cerrahi Polikliniğine Kasım 2013-Ocak 2015 tarihleri arasında medikal tedaviye dirençli dispeptik şikayetlerle başvuran hastalara yapılan gastroskopi sonuçları ve antrumdan alınan biyopsi sonuçları retrospektif olarak incelendi. Patoloji sonuçları HP değerlendirmesi için Giemsa, intestinal metaplazi değerlendirmesi için PAS-AB ile değerlendirildi. Bulgular: Toplam 682 hasta değerlendirildi. Hastaların 304 ü erkek, 378'i kadın hastaydı, yaş ortalaması 38,22 (±14,64); en genç hasta 18 yaşında, en yaşlı hasta ise 88 yaşındaydı. Yapılan endoskopik değerlendirme sonucu 555 (%81,4) antral gastrit; 81 (%11,9) pangastrit; 6 (%0,9) ülserovejetan kitle tespit edildi. Patolojik olarak 469 (%69,6) kronik aktif gastrit; 201 (%29,5) kronik inaktif gastrit; 6 (%0,9) adenokarsinom tespit edildi. 475 (%69,6) hastada HP; 56 (%8,2) hastada intestinal metaplazi, 11 (%1,6) hastada ise atrofi olduğu görüldü. Adenokarsinom tespit edilen 6 hastanın 4'ünde (%66,6) HP varlığı gösterildi. HP olan hastaların 48'inde intestinal metaplazi birlikteliği görüldü; 8 hastada ise intestinal metaplazi varlığında HP görülmedi. Helikobakter pilori varlığında intestinal metaplazi olması istatistiksel olarak anlamlı bulundu (p: 0,006). Tartışma: Helikobakter pilori midede yüksek oranda prekanseröz lezyon olan intestinal metaplaziye yol açabilmektedir. Genel cerrahi pratiğinde medikal tedaviye dirençli dispeptik şikâyetleri olan hastalar daha dikkatli değerlendirilmelidir.
Incidence of helicobacter pylori infection and gastric cancer : an 8-year hospital based study
Acta medica Indonesiana
To observe the tendency of decreased prevalence of H pylori infection in a 14 year-period and observe the prevalence of intestinal metaplasia and gastric cancer. All patients who were diagnosed with dyspepsia and underwent esophagogastroduodenoscopy in Cikini hospital Jakarta from January 1998 until December 2005 were evaluated. We evaluated the histopathologic result of H pylori, the presence of intestinal metaplasia and gastric cancer. Data was grouped for 1 year period of time and was presented descriptively. Decreased prevalence of H. Pylori infection was found, from 12.8% in 1998, 12.4% in 1999, 14.7% in 2000, 9.6% in 2001, 11.9 % in 2002, 3.8% in 2003, 2.3% in 2004, 2.9% in 2005. Intestinal metaplasia was 4.7% in 1998, 3.2% in 1999, 3.1% in 2000, 2.3 % in 2001, 7.6% in 2002, 8.3% in year 2003, 6.5% in 2004, 7.1% in 2005. Prevalence of gastric cancer was 2.2% in 1998, 0.25% in 1999, 1.1% in 2000, 1.1% in 2001, 1.1% in 2002, 1.8% in 2003, 1.7% in 2004, 3.9% in 2005. There was de...
Helicobacter, 2017
Background: Corpus-predominant gastritis index (CGI) is an early histological marker to identify Helicobacter pylori-infected gastric cancer relatives at risk of cancer. This study validated whether CGI is more prevalent in H. pylori-infected nonulcer dyspepsia (NUD) subjects than in duodenal ulcer (DU) controls and whether it is reversible after H. pylori eradication or is correlated with noninvasive biomarkers. Materials and Methods: In this longitudinal cohort study, 573 H. pylori-infected subjects were enrolled, including 349 NUD and 224 DU. Gastric specimens were provided to assess CGI, spasmolyic polypeptide-expressing metaplasia (SPEM), and Operative Link on Gastric Intestinal Metaplasia assessment (OLGIM). Serum pepsinogen I and II levels were assessed using enzyme-linked immunosorbent assay. CGI subjected were followed up at least 1 year after H. pylori eradication. Results: NUD subjects had higher prevalence rates of CGI (47.0% vs 29.9%, P<.001) and OLGIM stages III-IV (24.1% vs 15.2%, P=.01) than controls. CGI was highly prevalent in NUD subjects after the age of 40, which was 10 years earlier than atrophic gastritis and intestinal metaplasia. NUD subjects with CGI had higher risk of SPEM (OR 2.86, P<.001) and lower serum pepsinogen I/II ratios (P<.001) than those without CGI. Serum pepsinogen I/II ratios <9 could predict CGI modestly (AUROC 0.69, 95% CI: 0.63-0.74). CGI was regressed after eradication (P<.001). Conclusions: CGI was more prevalent in H. pylori-infected NUD subjects than in controls, was correlated with SPEM, and may serve as a marker earlier than OLGIM to indicate risk of gastric cancer. Moreover, CGI could be regressed after eradication. K E Y W O R D S corpus-predominant gastritis, gastric cancer screening, Helicobacter pylori, intestinal metaplasia, spasmolytic polypeptide-expressing metaplasia 1 | INTRODUCTION Gastric cancer is one of the top 10 leading cancers in terms of incidence worldwide and leads into significant economic and expected years of life lost. 1,2 Concerning its high prevalence and poor prognosis, early detection and prevention of gastric cancer should be an important part of public health policy. 3-5 Helicobacter pylori (H. pylori) is a class I carcinogen of gastric cancer, and nearly 80% of gastric adenocarcinoma is H.
Journal of Pathology of Nepal, 2020
Materials and Methods: This was a cross sectional study done at Kathmandu Medical College teaching Hospital in Pathology department from December 2018 to August 2019. The endoscopic biopsies were evaluated for intestinal metaplasia and Helicobacter pylori with the help of Hematoxylin and Eosin stains as well as Giemsa stain. Subtypes of intestinal metaplasia were classified with the help of periodic acidSchiff/Alcian Blue stain combination and High Iron DiamineAlcian Blue stain at pH 2.5. The relationship between Helicobacter pylori and subtypes of intestinal metaplasia were compared. Fisher’s exact test was used for statistical evaluation. A p value of ˂ 0.05 was considered as statistically significant.