Prodrugs for Nitroreductase Based Cancer Therapy‐5: Development of Trinitroaniline Prodrugs/Ssap‐NtrB Combinations for Liver Cancer Using Intracellular and Extracellular Conditions (original) (raw)

PRODRUGS FOR NITROREDUCTASE BASED CANCER THERAPY- 2: Novel amide/Ntr combinations targeting PC3 cancer cells

Tugba Taskin Tok

European journal of medicinal chemistry, 2019

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Prodrugs for nitroreductase-based cancer therapy-3: Antitumor activity of the novel dinitroaniline prodrugs/Ssap-NtrB enzyme suicide gene system: Synthesis, in vitro and in silico evaluation in prostate cancer

Tugba Taskin Tok

European journal of medicinal chemistry, 2020

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Prodrugs For Nitroreductase Based Cancer Therapy- 1 Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

Esra Tokay

Medicinal chemistry (Shariqah (United Arab Emirates)), 2017

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Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT)

Michael P Hay

Bioorganic & Medicinal Chemistry Letters, 1999

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Structure−Activity Relationships for 4-Nitrobenzyl Carbamates of 5-Aminobenz[ e ]indoline Minor Groove Alkylating Agents as Prodrugs for GDEPT in Conjunction with E. c oli Nitroreductase

Michael P Hay

Journal of Medicinal Chemistry, 2003

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Creation and screening of a multi-family bacterial oxidoreductase library to discover novel nitroreductases that efficiently activate the bioreductive prodrugs CB1954 and PR-104A

Alexandra Mowday

Biochemical Pharmacology, 2013

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Kinetic and Structural Characterisation of Escherichia coli Nitroreductase Mutants Showing Improved Efficacy for the Prodrug Substrate CB1954

Paul Race

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Interrogation of the Structure–Activity Relationship of a Lipophilic Nitroaromatic Prodrug Series Designed for Cancer Gene Therapy Applications

Maria Abbattista

Pharmaceuticals, 2022

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Kavita Sharma

Bioorganic & Medicinal Chemistry Letters, 2013

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Design, synthesis, molecular docking, and biological evaluation ofN-methyl-3-nitro-4-(nitromethyl)-4H-chromen-2-amine derivatives as potential anti-cancer agents

A Parthiban

Medicinal Chemistry Research, 2014

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Discovery of potent and novel S-nitrosoglutathione reductase inhibitors devoid of cytochrome P450 activities

Jan Wasley

Bioorganic & Medicinal Chemistry Letters, 2011

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Molecular docking studies of novel nitrophenyl inhibitor against aldose reductase

Dr. Murtaza Hajoori

International Journal of Research and Analytical Reviews, 2019

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Nitroaryl Phosphoramides as Novel Prodrugs for E. coli Nitroreductase Activation in Enzyme Prodrug Therapy

Patrick Browne

Journal of Medicinal Chemistry, 2003

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Synthesis and anticancer activity studies of ?-aminoalkylated conjugated nitroalkenes

namrata rastogi

Organic & Biomolecular Chemistry, 2006

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Metabolic Activation of the Antitumor Drug 5-(Aziridin-1-yl)-2,4-Dinitrobenzamide (CB1954) by NO Synthases

Nuala Helsby

Chemical Research in Toxicology, 2008

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Nitroreductase: A Prodrug-Activating Enzyme for Cancer Gene Therapy

David Kerr

Clinical and Experimental Pharmacology and Physiology, 2004

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Metabolic Activation of the Antitumor Drug 5-(Aziridin-1-yl)-2,4-Dmitrobenzamide (CB1954) by NO Synthases

Yves Frapart

Chemical Research in Toxicology, 2008

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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954

Paul Race

Cancer Research

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Nitroarylmethylcarbamate prodrugs of doxorubicin for use with nitroreductase gene-directed enzyme prodrug therapy

Michael P Hay

Bioorganic & Medicinal Chemistry, 2005

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Process Development and Protein Engineering Enhanced Nitroreductase-Catalyzed Reduction of 2-Methyl-5-nitro-pyridine

Ahir Pushpanath

Organic Process Research & Development, 2020

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Synthesis and biological properties of bioreductively targeted nitrothienyl prodrugs of combretastatin A-4

Peter Wardman

Molecular Cancer Therapeutics, 2006

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Synthesis, biological and electrochemical evaluation of novel nitroaromatics as potential anticancerous drugs

Bushra Mirza

Bioelectrochemistry, 2015

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Synthesis, Biological Evaluation, and Docking Studies of N-Substituted Acetamidines as Selective Inhibitors of Inducible Nitric Oxide Synthase

Mario Felaco

Journal of Medicinal Chemistry, 2009

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Generation of Escherichia Coli Nitroreductase Mutants Conferring Improved Cell Sensitization to the Prodrug CB19541

Paul Race

2003

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Design and Synthesis of Some Novel Aromatic Amide Derivatives of Nilutamide as In Vitro Anticancer Agents

Sirassu Narasimha

ChemistrySelect, 2020

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Optimised synthesis of a nitroCBI hypoxia-activated prodrug with substantial anticancer activity

Shangjin Yang

Tetrahedron, 2019

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Diminished toxicity of C-1748, 4-methyl-9-hydroxyethylamino-1-nitroacridine, compared with its demethyl analog, C-857, corresponds to its resistance to metabolism in HepG2 cells

Magdalena Niemira

Biochemical Pharmacology, 2012

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Activation of the c-Jun N-terminal Kinase/Activating Transcription Factor 3 (ATF3) Pathway Characterizes Effective Arylated Diazeniumdiolate-Based Nitric Oxide-Releasing Anticancer Prodrugs

Joseph Saavedra

Journal of Medicinal Chemistry, 2011

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Biological evaluation of selected metronidazole derivatives as anti-nitroreductase via in silico approach

Moriam Adeoye

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