PERBANDINGAN JUMLAH SEL DAN INTI SEL RAKSASA TIPE BENDA ASING PASCAIMPLANTASIHIDROKSIAPATIT DAN KARBONAT APATIT (Kajian in vivo pada Subkutan Tikus) (original) (raw)

2013

Abstract

Hydroxyapatite (HA) has a good bioactivity and osteoconductivity, but it is difficult to be resorbed by the body. Carbonated hydroxyapatite (CHA) has the same advantages with HA, but it is easier to be resorbed by the body. Implantation of synthetic material initiates foreign body reaction, which is characterized by foreign body giant cells (FBGCs) formation. Soft tissue biocompatibility test is required prior clinical application of bone substitute since the material contact with the soft tissue upon application and can cause severe inflammatory response. The aim of this study is to evaluate the numbers of FBGC and their nuclei after implantation of HA and CHA. Hydroxyapatite and CHA were implanted in subcutaneous tissue of the back of 12 male Rattus norvegicus. Each 3 rats were terminated after 7, 14, 21, 28 days of implantation. The implantation area was taken for histological preparations and stained with Haematoxylin-Eosin. The number of FBGCs and their nuclei were observed at ...

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