Loss of glutamate decarboxylase mRNA-containing neurons in the rat dentate gyrus following pilocarpine-induced seizures (original) (raw)

This study investigates the vulnerability of glutamic acid decarboxylase (GAD) mRNA-containing neurons in the dentate gyrus following seizures induced by pilocarpine in Sprague-Dawley rats. Using in situ hybridization and histological analyses, researchers found a significant decrease in GAD mRNA-containing neurons in the hilus of the dentate gyrus post-seizure, with no corresponding change in other regions. These findings suggest that a specific subset of GAD neurons in this region is particularly susceptible to seizure-induced damage, contributing to the understanding of GABAergic neuron functionality in epilepsy.