Cryotherapy for Treatment of Anogenital Warts (original) (raw)
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Treatment of Genital Warts with a Combination of Cryotherapy and 5% Imiquimod
JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2020
A 34-year-old married; female patient came to the dermatology outpatient section with the chief complaint of raised lesions over her external genitalia for the past four months which were associated with itching. The lesions initially were smaller in size and which gradually increased to the present size. She took a consultation with a private practitioner, details of which were not available, but some oral medications were prescribed. However she failed to adhere to the treatment protocol.
Journal of the American Academy of Dermatology, 1997
Background." Surgical procedures used to remove genital warts (cryotherapy, electrodesiccation) are painful. Attempts to reduce the discomfort of surgery by prior lidocaine infiltration anesthesia are compromised by the pain of the infiltration. Objective: Our purpose was to determine the efficacy of topically applied lidocaine/prilocaine cream to reduce the pain of lidocaine infiltration and the pain associated with cryotherapy to remove genital warts. Methods: Men, scheduled for removal of genital warts by cryotherapy, were randomly selected to receive one of three treatments: (1) lidocaine/prilocaine cream application, (2) 1% lidocaine infiltration, and (3) lidocaine/prilocaine cream application followed by infiltration of 1% lidocaine. Results: Application of lidocaine/prilocaine cream for 15 minutes markedly reduced the pain of lidocaine infiltration. The combination of lidocaine/prilocaine cream followed by infiltration of 1% lidocaine gave greater pain relief from the cryotherapy than did either anesthetic alone.
Cryotherapy for the management of genital warts in pregnancy: a five-year observational study
Objective: This observational study aims to review our experience in using cryotherapy for the management of genital warts during pregnancy over a five-year period. Methods: Fifty-three pregnant women with established genital warts were managed during the period from January 2000 to April 2005. There were 23 patients in the first trimester, 22 in the second, and 8 in the third trimester. Base line laboratory investigations were performed to establish any abnormalities and any other concurrent sexually transmitted diseases before starting treatment in each patient. Sexual abstinence or the use of protective barriers was advised to all patients. Cryotherapy was performed for the treatment of all genital warts. The treatment was on an out-patient basis, and the women were followed up every two weeks throughout pregnancy, and every month afterwards until nine months post delivery. Infants were also examined at birth and at nine months of age. Results: There was dramatic response to loca...
Dermatology Research and Practice
Background. Cryotherapy (freezing by liquid nitrogen) is an effective and widely used method for treatment of common warts. Patients often need multiple sessions at variable intervals. Protocols used by different dermatologists vary in terms of freezing time, the number of cycles, and the intervals between sessions. Aim. To compare the efficacy (cure rates) and safety (complications, early and late) of two cryotherapy treatment protocols for common viral warts. Method. A prospective observational study was conducted; it involved 80 patients with common warts on the hands and feet who were treated with cryotherapy done by two dermatologists who use different protocols; group 1 (45 patients) were treated by a single cycle of 10 seconds of freezing at 2 weekly intervals, and group 2 (35 patients) received a single cycle of 20 seconds of freezing at 4-weeks intervals. The two protocols were compared in terms of cure rate and complications 1-2 months after the final treatment. Recurrence...
Dermatology and therapy, 2017
Cutaneous warts are common skin lesions, caused by human papillomavirus. For years, liquid nitrogen is the cryogen of choice for wart treatment. Alternatively, several cryogenic devices for home treatment are commercially available. The present trial assessed efficacy and safety of a novel nitrous oxide-based cryogenic device for home use (EndWarts Freeze in Europe, Compound W Nitro-Freeze in the USA). This investigator-blinded, controlled, randomized study compared the nitrous oxide device (test product) with a dimethylether propane-based product (Wartner; comparator 1). Subjects with common or plantar warts (50/50 ratio) were randomized into two groups (n = 58, test product; n = 40, comparator 1). Sequentially, an extra treatment arm (n = 40) was added to compare with a dimethylether-based product with metal nib (Wortie; comparator 2). Main objective implied comparison of the percentage cured subjects after one to maximum three treatments. Efficacy and safety was evaluated by a bl...
Dermatology and Therapy
Introduction: Anogenital warts (AGW) are a relevant clinical issue in the field of sexually transmitted disease, and to date no treatment provides a satisfactory clearance rate. Treatment can be both medical and surgical, and be provided by a healthcare provider or by the patient. Cryotherapy (CRYO) is among the most common treatments for AGW. NitrizincÒ Complex solution (NZCS) is a solution containing organic acids, nitric acid and zinc and copper salts that is applied topically to warts, producing mummification of the damaged tissue. It is considered to be an effective and well-tolerated treatment for genital and common warts. The aim of our study was to compare NZCS to CRYO in the treatment of AGW. Methods: We performed a prospective, multicentre, single-blind, randomised, superiority clinical study involving 120 patients, aged 18-55 years, diagnosed with a first episode of AGW, with each patient having from three to ten AGW. The patients were treated either with NZCS or CRYO for a maximum of four treatments. Primary endpoints were: (1) comparison of the clinical efficacy of CRYO and NZCS, based on response to treatment (clearance of AGW) within four treatment sessions; and (2) tolerability, assessed via a short questionnaire at the end of each treatment session. Secondary endpoints were: (1) number of treatments needed for clearance; and (2) recurrence at 1 and 3e months after confirmed clearance. The results were analysed on an intention-to-treat basis. Results: A complete response was achieved in 89.7% of the NZCS group and in 75.4% of the CRYO group (p = 0.0443). NZCS was found to be better tolerated. There was no difference between the NZCS and CRYO treatment arms in the number of sessions needed to clear the lesions. Recurrence occurred after 1 month in 18.4% of the NZCS group and 38.1% of the CRYO group (p = 0.0356), and after 3 months in 25 and 40.6% of these groups, respectively (p = 0.1479).
Journal of Obstetrics Gynecology and Cancer Research, 2017
Anogenital warts (AGWs) are the most prevalent sexually transmitted viral infections in the United States of America. Symptomatic warts can be seen in nearly 1% of the population aged 15 to 49 years. Genital warts are highly contagious through sexual contact. AGWs can be diagnosed by careful visual inspection. Several methods have been described for the treatment of warts; however, all have their own limitations and are not always successful. Warts often recur even after being completely removed. The treatments of warts can be divided into two broad categories, ie, surgical and nonsurgical methods. The patient himself/herself can apply the nonsurgical methods, or a physician can perform it. Podophyllotoxin is a good medical substance. Imiquimod can act as an immune response modifier and stimulate locally produced cytokine. Topical treatments of warts increase local production of interferon and decrease viral load of human papiloma virus (HPV). The surgical methods for genital warts include curettage, electrosurgery, and application of a scalpel under general or local anesthesia. Scattered keratinized lesions can be removed by electrosurgery. Patients with multiple or large warts of any location should be referred for surgical treatment under general anesthesia.
Journal of Dermatological Treatment, 2014
Introduction: All available treatments for anogenital warts have substantial failure rates. An immunomodulating treatment that enhances the patient's own immunity could be valuable as an adjuvant to conventional methods. Methods: About 123 patients were enrolled in this study and were randomized either to undergo only cryotherapy every 3 weeks (n ¼ 60 patients) or to undergo cryotherapy and to receive a mixture containing 20 mg sterol and 0.2 mg sterolin (BSS-BSSG mixture), known for its immunomodulating properties (n ¼ 63). Results: A complete response after 3 months was demonstrated by 18.3% of the patients in the first group and 30.2% of the second group, while 61.7% of the first group and 79.4% of the second group were lesion free at the end of the 6-month follow-up period. Cox regression analysis of the time until response showed a significant advantage to the mixture treatment group (hazard ratio 2.76, 95% confidence interval 1.61-5.67). Limitations: The study was not placebo controlled. Conclusion: The BSS-BSSG mixture gave promising results as an adjuvant to cryotherapy and may be used in patients with refractory warts.