Alteration of time-resolved autofluorescence properties of rat aorta, induced by diabetes mellitus (original) (raw)

Laser Physics, 2016

Abstract

Changes in autofluorescence properties of isolated rat aorta, induced by diabetes mellitus, were detected using time-resolved fluorescence spectroscopy with pulsed ultraviolet (UV) laser excitation. We demonstrated that time-resolved spectroscopy was able to detect changes in aorta tissues related to diabetes and unambiguously discriminate diabetic (τ 1 0.63 ± 0.05 ns, τ 2 3.66 ± 0.10 ns) samples from the control (τ 1 0.76 ± 0.03 ns, τ 2 4.48 ± 0.15 ns) group. We also report changes in the ratio of relative amplitudes of the two lifetime component in aorta tissue during diabetes, most likely related to the pseudohypoxic state with altered NADH homeostasis.

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