Spectrum of Thyroid Carcinomas in Coastal Andhra Pradesh: A Retrospective Study (original) (raw)
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Epidemiology of Thyroid Lesions in Wardha District of Central India
Journal of Evidence Based Medicine and Healthcare, 2015
To establish a significant predominance of thyroid lesions in and around Wardha district, and to establish specific etiological link for the predominance the thyroid lesions. MATERIALS AND METHODS: This was a hospital based analytical prospective study, conducted in Acharya Vinobha Bhave Rural Hospital (A.V.B.R.H.) involving 108 patients. The study was carried over a duration of 1 year January 2010 to December 2010. Patients attending endocrinological clinics and the newly detected cases of thyroid lesions, within set parameters of study, were the subjects of this study. OBSERVATION: Thyroid lesions which we came across in the course of the study were Thyrotoxicosis, Myxoedema, Thyroiditis, Diffuse goitre, Nodular Goitre and Carcinoma Thyroid. These were correlated with epidemiological factors like Age, Sex, Region, Diet and Iodine Intake. Significant relationship between thyroid function, age of patient, diet was seen in comparison to individual thyroid lesions. CONCLUSION: Goitre was the commest pathology encountered. Almost all of the thyroid lesions were of hypothyroid in their function with exception of thyrotoxicosis and carcinoma. Thyroid lesions were found predominantly in females, Age related lesion pathology was significant, and vegetarian and nonvegetarian diets along with low and high iodine salt uptake had obvious pathological effects on thyroid.
International Journal Of Community Medicine And Public Health, 2020
Background: Diseases of thyroid are of great importance since most of them are amenable to surgical or medical management. Objective of this study was to study the incidence, gender profile, intervention undertaken, fine needle aspiration cytology and histopathological profile of thyroid lesions and correlation of FNAC and HPE studies done after surgical intervention.Methods: This is a prospective study of the patients with thyroid swelling presenting to the head and neck clinic of otorhinolaryngology and head and neck surgery, Dayanand Medical College, Ludhiana over a time period of 2 years (January 2018 to November 2019). All the cases were subjected to a thorough clinical examination followed by evidence-based interventions. Fine needle aspiration cytology was done in all the cases preoperatively as out-patients basis and histopathologically confirmed postoperatively.Results: There were 80/212 subjects presenting in outpatient head and neck clinics of otorhinolaryngology and head...
National Journal of Laboratory Medicine, 2016
Introduction: Fine Needle Aspiration Cytology (FNAC) of the thyroid gland is a widely accepted, cost effective and accurate method for evaluation of thyroid lesions. Cytology of thyroid gland has therefore become the first line diagnostic test in preoperative assessment. A thorough clinical examination, Thyroid Function Tests (TFT) and Ultrasonographic (USG) assessment of these lesions give invaluable information to reach a cytological diagnosis. Aim: To classify thyroid cytological diagnosis according to the Bethesda System of Reporting Thyroid Cytology (TBSRTC), which would help in planning prognostic and therapeutic approaches. The cytological diagnosis was also correlated with the clinical findings, TFT and USG findings. Materials and Methods: The present study was conducted in the Department of Pathology, Basaveshwar Hospital attached to M.R. Medical College, Kalaburagi, Karnataka. The study was conducted from 01/07/2012 to 31/12/2014 (30 months), India. Total 120 cases were ca...
International Journal of Advances in Medicine, 2014
Thyroid nodules are commonly encountered in clinical practice, with a prevalence of 2% to 5% for palpable thyroid nodules 1 and 19% to 46% for nodules detected by thyroid ultrasonography. 2 Thyroid nodules are more common in women, and the incidence increases with age, history of radiation and diet containing giotrogenic material. 1 Various studies have shown that the risk of malignant involvement of thyroid palpable nodules 3 is 4% to 7%. Clinically thyroid lesions present as goitre or thyroid enlargement which can be nodular (solitary or multiple) or diffuse. 3
South Asian Journal of Cancer
Introduction Goiter is one of the most common conditions encountered clinically (up to 60% of population) with thyroid malignancy being one of the most common endocrine malignancies. The American Thyroid Association has advocated the need for validation of the Bethesda system of fine needle aspiration cytology (FNAC) in each center. The risk of malignancy (ROM) for Bethesda categories in the Indian population is limited. Objective As there are variations in the effectiveness of FNAC, this study aims to study the role of FNAC in evaluating thyroid nodules, estimating the risk of malignancy in thyroid nodules in the North-East Indian population, and correlating the FNAC findings with HPE (histopathological examination). Materials and Methods A total of 110 patients with thyroid nodules had visited the Department of Otorhinolaryngology during 2017–2020. Case records were retrieved, out of which only 66 patients had both FNAC and HPE reports. The FNAC of 66 patients were studied. Statis...
IP Innovative Publication Pvt. Ltd., 2017
Introduction and Objective: Thyroid gland lesions are seen worldwide with geographical variation in incidence and histopathological pattern related to age, sex, dietary and environmental factors. This study is aimed to describe the histomorphological spectrum of thyroid lesion in relation to age, sex distribution and also to compare the findings with other studies done in India and elsewhere. Materials and Method: It is a prospective study of all thyroidectomy specimens received from June 2015-Dec 2016 in department of pathology, Dr. B R Ambedkar Medical College, Bengaluru. Results: A total of 100 cases were studied. Female to male ratio was 6:1. The age group ranged from 12-75yrs with peak incidence seen at 35-45yrs. The lesions were classified as non-neoplastic and neoplastic. Non-Neoplastic lesions were more common and accounted for 82% and neoplastic lesions accounted for 18%. The most common lesion was goiter (68%), followed by thyroid adenomas (16%) and thyroid carcinomas (2%). There were 7 cases of toxic goitre (7%), 4 cases of thyroglossal cyst (4%) and 3 cases of thyroiditis (3%). Conclusion: The study shows that thyroid gland diseases are seen in both genders with female preponderance. Among the varied histomorphological spectrum of surgical lesions of thyroid, colloid goiter is the most common lesion. Follicular adenoma is the commonest benign tumor and a higher incidence of follicular carcinoma was seen.
Study of histopathological patterns of thyroid lesions in rural medical college
IP innovative publication pvt. ltd, 2019
Aim and objectives: To study histopathological features of thyroid lesions, their age and sexwise distribution and frequency of thyroid lesions in thyroidectomy specimens in rural population along with their benign and malignant behaviour. Materials and Methods: Present study is cross-sectional retrospective study conducted between January 2014 to December 2018 for period of five years, at the department of Pathology JIIU’S IIMSR WARUDI, Rural Medical College Badnapur, Jalna in Maharashtra. All the thyroidectomy specimens received for histopoathological examination during year 2014 to 2018 in Department of Pathology, were included in present study Result: Out of 233 cases studied, 204 were females [87.55%] and 29 were males [12.45%]. Mean age of presentation was 34.68 yrs. Range of the age of presentation was 2yr-70 yr. with maximum patients [60.52%] between 21-40 yrs. There were 191 non-neoplastic lesions [81.97] and 42 were neoplastic [18.03]. Most common non-neoplastic lesions were hyperplastic lesions 149 cases [63.95%]. Multinodular goitre was most common hyperplastic lesion. [47.21%]. Second most common non-neoplastic lesions were congenital lesions 18 cases [7.72%] with most common congenital lesion being Thyroglossal cyst [6.44%]. Inflammatory lesions were found to be [6.44%], all were Hashimoto thyroiditis. Out of 42 neoplastic cases, 29 were benign [12.45%] and 13 were malignant [5.58%]. Follicular adenoma was found to be most common benign neoplastic lesion [10.73%].Papillary carcinoma was found to be most common malignant neoplastic lesion [3%]. Conclusion: Study shows that thyroid gland lesions were common amongst rural population in Jalna district with females out-numbering males. Non-neoplastic lesions were more common than neoplastic lesions. Benign lesions out-numbered malignant lesions. Multinodular goitre was found to be commonest non-neoplastic lesion. Follicular adenoma was found to be most common benign neoplasm, while papillary thyroid carcinoma was found to be commonest malignant neoplasm. Though other modalities like, FNAC and Sonography were useful in diagnosis of most of the cases, Histopathological examination was found to be mainstay for final diagnosis. Keywords: Rural, Thyroid lesions, Histopathology, Goitre, Adenoma, Carcinoma.
Nepal Journal of Health Sciences
Introduction: Thyroid nodules brought to a hospital are checked for cancer. A post-operative histological examination is a gold standard for diagnosing thyroid lesions. Treatment is aided by a prior understanding of the disease’s underlying pattern. Objective: A retrospective study was done to determine the prevalence and distribution of malignancy in suspicious thyroid nodules. Methods: The study was conducted at Ganesh Man Singh Memorial Academy of ENT- Head and Neck studies from August 2017 to March 2020. All the subjects (n=183) presenting with a thyroid nodule and who had post-operative histopathological evaluation available were recruited in the study. The proportion and percentage of findings of Fine Needle Aspiration Cytology (FNAC) and histopathological evaluation were done. The distribution of histopathological observation was also analyzed in terms of age group and gender. Results: The mean age of study participants was 40.23 ± 13.77 years (n=183). The predominance of wom...
Spectrum of Thyroid Dysfunction in North Coastal Andhra Pradesh
Journal of Evidence Based Medicine and Healthcare, 2018
BACKGROUND The pathological spectrum of thyroid dysfunction varies from overactive to underactive thyroidism. It is a common Endocrine disorder worldwide and leads to major consequences in the absence of appropriate treatment. MATERIALS AND METHODS This is a hospital based retrospective study based on medical records from the period of January 2013 to December 2015. Thyroid hormones were evaluated by RIA for T3 & T4 and IRMA for TSH, kits supplied by BRIT, Mumbai. RESULTS 2322 study subjects comprised of males 403 and 1919 females. Thyroid dysfunction categorized was as hypothyroidism, subclinical hypothyroidism, hyperthyroidism and Subclinical hyperthyroidism as per reference values for thyroid hormones. Prevalence of thyroid dysfunction was 43.7% in females and females were more affected than males. Hypothyroidism 15.80% and Subclinical hypothyroidism 21.40% were higher than hyperthyroidism 3.91% and subclinical hyperthyroidism 2.58% subjects aged 30-45 years had a higher prevalence. Euthyroid subjects constituted 56.28%. CONCLUSION Study revealed high prevalence of abnormal thyroid function. Females and elderly are more susceptible. Since untreated thyroid disease leads to significant morbidity, public awareness in the context of primary care setting will be valuable.
BACKGROUND presence of thyroid lesion is a very common complaint in clinical practice especially in females in North Indian region, its diagnosis is commonly made on FNAC which is a minimally invasive technique performed on OPD basis easily. AIM: To study various thyroid lesions and their relationship with various demographic factors in the North Indian region. MATERIAL AND METHOD: The present study is a prospective study done in the postgraduate Department of Pathology of GMC Jammu from Dec 2020 to Nov2021. 146 cases were studied during this period in each case clinical history and physical examination was done before performing the FNAC (Ultrasound guided FNAC where ever required), due consideration was given to various demographic factors. And final reporting was done by The Bethesda System which is a uniform reporting system for thyroid cytology. RESULTS: Out of 146 cases 17.8%were males and 82.2% females, maximum cases were from age group of 21 to 30 years i.e 28.7 % followed by 31 to 40 years i.e 21.9% and least above 70 years and below 10 years age group i.e 1.3% each.31.5%belonged to rural area and 68.4 % to urban area.71.2% benign(cat 2) and 12.3% malignant (cat 6),6.8% non-diagnostic (cat 1),2.7% AUS/FLUS(cat 3),5.4%FN/SFN(cat 4) and 1.36% suspicious for malignancy (cat 5).