Immunoregulation in the Hematopoietic Stem Cell Niche (original) (raw)

2020

Abstract

Abstract The identification of cell populations of immunological origin and function in the hematopoietic stem cell (HSC) niche has unveiled an unconventional role of the niche in regulating HSC activity. These immune cells cooperate with the well-known properties of mesenchymal and vascular cells in orchestrating HSC quiescence, self-renewal, and differentiation by controlling local inflammation. Monocytes/macrophages and other diverse cells of myeloid origin, as well as conventional and regulatory T cells have been characterized as critical players. Interestingly, mesenchymal stromal cells might modulate many aspects of this complex cellular cross-talk, providing fundamental insights on how inflammation ultimately regulates tissue repair and regeneration.

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