Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities? (original) (raw)

Experimental Dermatology

Abstract

Pustular psoriasis is characterised by eruptions of neutrophilic sterile pustules. The European Rare and Severe Psoriasis Expert Network consensus defines pustular psoriasis into three subtypes; generalised pustular psoriasis (GPP), palmoplantar pustulosis and acrodermatitis continua of Hallopeau (ACH). Mixed forms are categorised according to their predominant features. However, the Japanese Dermatological Association includes ACH under the diagnosis of GPP. This article aims to review the similarities and differences between ACH and GPP. Based on our review, interleukin (IL)‐36RN mutations, the most frequent genetic findings in pustular psoriasis are found most commonly in GPP, followed by ACH. Genotypes of IL‐36RN mutations among GPP patients and ACH patients are different between European and Asian ethnicities. IL‐36 signalling pathway is the main mechanism. Metabolic diseases are common comorbidities and joint involvement can occur in 20.5%–36.4% of both conditions. Associated ...

Leena Chularojanamontri hasn't uploaded this paper.

Let Leena know you want this paper to be uploaded.

Ask for this paper to be uploaded.