Origins and perspectives of schizophrenia research (original) (raw)

This paper review the evolution of schizophrenia research, emphasizing its historical understanding and the shift towards modern neurobiological perspectives. It discusses the importance of comprehensive diagnostic systems, like the Composite Diagnostic Evaluation (CODE), and the multifactorial etiologies of schizophrenia, including genetic, environmental, and epigenetic factors. It highlights the complexity of schizophrenia's symptomatology, which includes positive, negative, and cognitive symptoms, as well as the implications of familial heritability and the challenges in identifying specific genomic factors.