The Red Cell Shape as an Indicator of Membrane Structure: Ponder’s Rule Reexamined (original) (raw)

Springer eBooks, 1978

Abstract

A recently published mathematical analysis allows the precise determination of the forces which acting on the red cell membrane cause any red cell to assume a particular shape. The effective use of this analysis in the study of membrane physiology and pathology, however, is dependent on the availability of large numbers of accurately measured RBC cross sections. Red cells under study must be suspended in physiologic solutions; this effectively limits the data gathering technique to light microscopy. The low resolving power of the light microscope causes a diffraction band to overlie the membrane and renders the determination of the actual membrane location difficult. This problem was first examined by Ponder in 1930, when he formulated a technique that has come to be known as ‘Ponder’s Rule’.

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