Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study (original) (raw)

2016, Frontiers in Medicine

AI-generated Abstract

This study investigates the relationship between acute respiratory distress syndrome (ARDS) and plasma concentrations of coagulation and fibrinolysis markers, specifically tissue factor (TF), tissue plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) in mechanically ventilated patients. Conducted as a prospective observational pilot study, it includes patients with PaO2/FiO2 < 300 mmHg at increased risk of ARDS. Significant findings reveal that higher median plasma concentrations of TF and PAI-1 correlate with ARDS development, while t-PA levels remained unchanged. The sensitivities and specificities for TF and PAI-1 suggest potential for these biomarkers in early diagnosis and risk assessment of ARDS.