Activation of Coagulation and Fibrinolysis in Acute Respiratory Distress Syndrome: A Prospective Pilot Study (original) (raw)

This study investigates the relationship between acute respiratory distress syndrome (ARDS) and plasma concentrations of coagulation and fibrinolysis markers, specifically tissue factor (TF), tissue plasminogen activator (t-PA), and plasminogen activator inhibitor-1 (PAI-1) in mechanically ventilated patients. Conducted as a prospective observational pilot study, it includes patients with PaO2/FiO2 < 300 mmHg at increased risk of ARDS. Significant findings reveal that higher median plasma concentrations of TF and PAI-1 correlate with ARDS development, while t-PA levels remained unchanged. The sensitivities and specificities for TF and PAI-1 suggest potential for these biomarkers in early diagnosis and risk assessment of ARDS.