Niveles de antitoxina tetánica y diftérica en recién nacidos y niños preescolares cubanos (original) (raw)
Related papers
2006
A randomized, controlled and double-blind trial was carried out in 225 Cuban teenagers aged 13-16 to evaluate the reactogenicity and immunogenicity of a new tetanus toxoid and reduced diphtheria toxoid vaccine (Finlay Institute) with respect to IMOVAX dT adult control vaccine (Aventis Pasteur). Serum samples were taken before and 21 days after immunization. The reactogenicity of both vaccines was similar. The general and local adverse events were mild and mainly detected in the first 72 hours after vaccination. All volunteers showed protective levels of tetanus antitoxin and diphtheria antitoxin (≥0.1 IU/mL). 99.25% of subjects who received the experimental vaccine and 98.36% of control subjects showed long-term protective values of tetanus antitoxin (≥1.0 IU/mL). These diphtheria antitoxin levels were respectively detected in 81.20% and 80.33% of volunteers. The geometric mean titer values for tetanus antitoxin and diphtheria antitoxin induced after vaccination were 21.73 IU/mL and 2.55 IU/mL respectively, higher than antitoxin levels of control group: 15.55 IU/mL and 1.84 IU/mL respectively (p<0.05).
VacciMonitor, 2021
La uveítis anterior no infecciosa es una enfermedad inflamatoria del ojo que afecta al tracto uveal y que puede causar ceguera total y otras discapacidades visuales. Esta enfermedad se ubica en el espectro de enfermedades autoinmunes y autoinflamatorias. Se han descrito respuestas no adecuadas a la vacunación en enfermedades mediadas por el sistema inmune, por lo que se evaluaron los niveles de antitoxina tetánica y diftérica en pacientes cubanos con uveítis anterior no infecciosa, relacionada con el alelo HLA-B27. Se determinaron los niveles de antitoxina tetánica y diftérica mediante ELISA en 190 pacientes con uveítis anterior no infecciosa y controles supuestamente sanos. El 97,37% de los pacientes con uveítis mostraron niveles de protección de antitoxina tetánica mayor o igual a 0,1 UI/mL, similar a lo observado en los controles sanos (98,95%) (p=0,4385). Las proporciones de pacientes con uveítis anterior no infecciosa y sus controles en los diferentes niveles de protección de a...
Enfermedades Infecciosas y Microbiología Clínica, 2001
Nasal carriers of methicillin-resistant Staphylococcus aureus among cuban children attending day-care centers BACKGROUND. Recent but scarce reports of methicillin-resistant Staphylococcus aureus strains (M RSA) among children w ithout risk factos associated w ith its acquisition promted us to investigate its presence in the community. PATIENTS AND M ETHODS. During the September and October months in 1997, nasal and pharyngeal sw abs w ere obtained from 358 children aged less than five years w ho attended three day-care centers in the M arianao Area, La Habana City, Cuba. The isolated S. aureus strains w ere characterized for antimicrobial sensitivity using the Kirby-Bauer method. M ethicillin resistance w as confirmed by te Oxacillin Salt-Agar Screening-Plate˝ method recommended by the National Committee for Clinical Laboratory Standards. RESULTS. 18.7% of children w ere carriers of S. aureus in the upper respiratory tract; 2.2% of children carried M RSA strains. The highest resistance levels corresponded to erythromycin (50.74%) and tetracycline (29.9%). All tested strains w ere sensitive to ciprofloxacin. CONCLUSIONS. Our results provide evidence on the recovery of M RSA strains among healthy children attending daycare centers and are suggestive of a rapid colonization and spread of these microorganisms in the community.
Revista Habanera De Ciencias Medicas, 2013
Introduction: the Titanic antitoxin quantification is useful to assess the immune response against vaccinal antigens. Objective: to develop a standardization and validation technique of the indirect ELISA to quantify titanic antitoxin in human serum. Materials and Methods: the standard preparing to the assay curve was calibrated front the preparing Finlay Institute. The optimal indicators were normalized to each technique step developed. Results: a good intra-assay precision was reach during validation in all cases. The coefficient of variation to parallelism was less than 10% and 110%. Detection limit was 0.002 UI/ ml. Analytic sensitivity reached was 0.01 UI/ ml. Conclusions: the assay may be used to quantify Titanic antitoxin in human serum.
Susceptibilidad a antimicrobianos de patógenos respiratorios en niños provenientes de la comunidad
2004
OBJETIVO: Determinar la resistencia de los patógenos respiratorios a diferentes antimicrobianos. MATERIAL Y MÉTODOS: Entre abril y noviembre de 2002 se estudió 177 pacientes que asistieron al consultorio externo de otorrinolaringología del Hospital Nacional Docente Madre-Niño San Bartolomé. RESULTADOS: Streptococcus pneumoniae fue la bacteria patógena más aislada (57,2%), luego Moraxella catarrhalis (42,7%), Staphylococcus aureus (18,6%) y en pequeña cantidad Haemophilus influenzae (3,4%) y Streptococcus pyogenes (0,7%). Streptococcus pneumoniae presentó 31,3% de resistencia a la penicilina. El 96,7% de Moraxella catarrhalis fueron productoras de betalactamasa y 7,4% de los Staphylococcus aureus fueron resistentes a la oxacilina. CONCLUSIÓN: Streptococcus pneumoniae es el principal agente causal de los procesos infecciosos altos en niños y su resistencia a la penicilina aumentó a 31,3%