Synthesis, Physicochemical Characterization, and Biological Activities of New Carnosine Derivatives Stable in Human Serum As Potential Neuroprotective Agents (original) (raw)
2010, Journal of Medicinal Chemistry
The synthesis and the physico-chemical and biological characterisation of a series of carnosine amides bearing on the amido group alkyl substituents endowed with different lipophilicity are described. All synthesised products display carnosine-like properties differentiating from the lead for their high serum stability. They are able to complex Cu 2+ ions at physiological pH with the same stoichiometry as carnosine. The newly synthesised compounds display highly significant copper ion sequestering ability and are capable of protecting LDL from oxidation catalysed by Cu 2+ ions, the most active compounds being the most hydrophilic ones. All the synthesised amides show quite potent carnosine-like HNE quenching activity; in particular, 7d, the member of the series selected for this kind of study, is able to cross the blood-brain barrier (BBB) and to protect primary mouse hippocampal neurons against HNE-induced death. These products can be considered metabolically stable analogues of carnosine and are worthy of additional investigation as potential neuroprotective agents.
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