The effect of aging on cochlear amplifier: A simulation approach using a physiologically-based electro-mechanical model of the cochlea (original) (raw)

Age-related hearing loss is a prevalent condition in older adults, often linked to metabolic presbyacusis, characterized by a decline in the endocochlear potential (EP). Existing computational models insufficiently account for the physiological details of the cochlea, leading to challenges in understanding specific cochlear impairments. This research introduces a physiologically-based electro-mechanical model of the cochlea that integrates electrical, acoustical, and mechanical elements, enabling simulation of cochlear lesions and validation of the metabolic presbyacusis hypothesis. Results indicate that reduced EP significantly impacts cochlear amplification, particularly at higher frequencies, implicating the need for further clinical validation and integration with other auditory system models.