original ) (raw )Structure based identification of novel inhibitors against ATP synthase of Mycobacterium tuberculosis: A combined in silico and in vitro study
Ruben Cloete
International Journal of Biological Macromolecules, 2019
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Structural Basis for the Inhibition of Mycobacterium tuberculosis Glutamine Synthetase by Novel ATP-Competitive Inhibitors
Mats Larhed
Journal of Molecular Biology, 2009
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in silico Quest Guided by Physico-Chemical Descriptors of Bedaquiline for New Scaffolds with Potential Inhibitory Capacity against Homology Model of Mycobacterium F1F0 ATP Synthase
Vijjulatha Manga
Asian Journal of Chemistry, 2018
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Scaffold Morphing Led to Evolution of 2,4-Diaminoquinolines and Aminopyrazolopyrimidines As Inhibitors of ATP Synthesis Pathway
Anandkumar Raichurkar
Med. Chem. Commun., 2016
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Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors
Mats Larhed , Luke Odell
Bioorganic & Medicinal Chemistry Letters, 2009
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Scaffold morphing leading to evolution of 2,4-diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway
ramanatha saralaya
MedChemComm, 2016
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Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis
Raj Khan
Bioorganic & Medicinal Chemistry, 2015
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Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels
Garrett C Moraski
Antimicrobial Agents and Chemotherapy
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Trisubstituted Imidazoles as Mycobacterium tuberculosis Glutamine Synthetase Inhibitors
Luke Odell , Mats Larhed
Journal of Medicinal Chemistry, 2012
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An amiloride derivative is active against the F1Fo-ATP synthase and cytochrome bd oxidase of Mycobacterium tuberculosis
Kurt Krause
Communications biology, 2022
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Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB
Chrystala Constantinidou
PLoS ONE, 2012
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Optimization of Pyrrolamides as Mycobacterial GyrB ATPase Inhibitors: Structure-Activity Relationship and In Vivo Efficacy in a Mouse Model of Tuberculosis
S. Hoffner
Antimicrobial Agents and Chemotherapy, 2014
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New Insights to Resistance of a Novel Drug Bedaquiline using in-vitro Mutants of ATP Synthase in Mycobacterium Tuberculosis
Nusrath Unissa
2018
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Structure–activity relationship for nucleoside analogs as inhibitors or substrates of adenosine kinase from Mycobacterium tuberculosis
William G Parker
Biochemical Pharmacology, 2006
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Corrigendum to “Novel, potent, orally bioavailable and selective mycobacterial ATP synthase inhibitors that demonstrated activity against both replicating and non-replicating M. tuberculosis” [Bioorg. Med. Chem. 23 (2015) 742–752]
Shaheb Raj Khan
Bioorganic & Medicinal Chemistry, 2015
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Biological evaluation of novel substituted chloroquinolines targeting mycobacterial ATP synthase
Sohail Akhtar
International Journal of Antimicrobial Agents, 2012
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Design, synthesis, and biological evaluation of novel imidazo[ 1,2‐a ]pyridinecarboxamides as potent anti‐tuberculosis agents
karen Arreola
Chemical Biology & Drug Design, 2020
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Synthesis, biological activity, and molecular modeling investigation of new pyrazolo [4, 3-e]-1, 2, 4-triazolo [1, 5-c] pyrimidine derivatives as human A3 adenosine …
Hema Latha
Journal of medicinal …, 2002
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Variations of Subunit of the Mycobacterium tuberculosis F1Fo ATP Synthase and a Novel Model for Mechanism of Action of the Tuberculosis Drug TMC207
Srinivasa Rao
Antimicrobial Agents and Chemotherapy, 2013
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A computational model of the inhibition of Mycobacterium tuberculosis ATPase by a new drug candidate R207910
Anil Koul
Proteins, 2007
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Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone
Hélène Munier-lehmann
European Journal of Medicinal Chemistry, 2010
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A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis
Luis Antonio Ramírez Camacho
ACS Chemical Biology, 2012
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Interpretation of the mechanism of action of antituberculosis drug bedaquiline based on a novel two-ion theory of energy coupling in ATP synthesis
Sunil Nath
Bioengineering & Translational Medicine
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Advancement of Imidazo[1,2- a ]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis
Garrett C Moraski
ACS Medicinal Chemistry Letters, 2013
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Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase
Clare E M Stevenson
Journal of Antimicrobial Chemotherapy, 2020
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Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase
Koen Andries
PLoS ONE, 2011
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