Prevotella intermedia: uma breve revisão (original) (raw)

Periodontia, 2015

Abstract

Prevotella intermedia e um microrganismo anaerobio Gram negativo, considerado um dos agentes etiologicos de doencas periodontais. Tendo em vista que o biofilme subgengival e um dos seus principais habitats, qualquer quebra na homeostase do meio pode favorecer seu desenvolvimento e consequente dano aos tecidos atingidos. Diversas pesquisas vem sendo realizadas a fim de identificar o papel deste microrganismo nas doencas periodontais. Assim, este trabalho teve por objetivo revisar a literatura para coletar informacoes sobre as caracteristicas e efeitos de Prevotella intermedia no contexto saude-doenca periodontal. A busca foi realizada nas bases de dados PubMed e Lilacs, bem como atraves de uma busca aleatoria. De um total de 47 artigos incluidos, alguns principais resultados puderam ser destacados: Prevotella intermedia esta fortemente associada ao quadro de doencas periodontais e suas caracteristicas favorecem o acometimento e intensificacao de doencas diversas. Alem disso, este microrganismo e capaz de produzir pigmentos e uma variedade de enzimas as quais favorecem danos aos tecidos periodontais. Existem varias caracteristicas que aumentam a patogenicidade e virulencia deste microrganismo, como por exemplos a sua capsula polissacaridica, a presenca de enzimas protetoras contra o oxigenio, a presenca e producao de proteases, alem da estimulacao de fatores de crescimento no hospedeiro. Nao ha consenso na literatura acerca da relacao de causa-efeito entre presenca de Prevotella intermedia e diabetes. Contudo, este microrganismo parece estar envolvido no quadro de pacientes HIV positivo. Por fim, e importante salientar que Prevotella intermedia pode adquirir resistencia a alguns tipos de antibioticos, e, por isso, o seu controle e um desafio a clinica atual...(AU) Prevotella intermedia is a Gram negative anaerobic microorganism, considered one of the etiologic agents of periodontal diseases. Taking into account that the subgingival biofilm is its major habitat, any break of the environment homeostasis may lead to the development of the microorganism and consequent damage to the surrounding tissues. Several researches have been conducted in order to identify the role of this microorganism in the periodontal diseases. Thus, this study aimed to review the literature in an attempt to collect information about the characteristics and effects of Prevotella intermedia in the periodontal healthdisease context. The search was performed in the PubMed and Lilacs databases, as well as under a random search. From a total of 47 included articles, some major results could be drawn: Prevotella intermedia is strongly related to the occurrence of periodontal diseases, and its characteristics lead to the incidence of several diseases. Moreover, this microorganism is able to produce pigments and a variety of enzymes, which potentiate the damage of periodontal tissues. There are several characteristics that increase the pathogenicity and virulence of this microorganism, including the polyssacharidic capsule, the presence of protective enzymes against oxygen, the presence and production of proteases, as well as the stimulation of grow factors in the host. There is no consensus in the literature regarding the cause-effect relationship between the presence of Prevotella intermedia and diabetes. However, this microorganism seems to be involved in the occurrence of HIV-positive people. Lastly, it is worth to mention that Prevotella intermedia may acquire strength to some antibiotic types, and, therefore, its control is a challenge to the current clinic...(AU)

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