A COMPARATIVE STUDY ON THE EFFECT OF FLUOROQUINOLONES IN EXPERIMENTAL SEIZURES ON WISTAR RATS: AN ACUTE STUDY Original Article (original) (raw)
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Proconvulsive Profile of Fluoroquinolones-An Experimental Study with Clinical Co-Relations
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There have been several reports that convulsions, although rare, occur in patients who receive fluoroquinolones. In this study, the proconvulsant effects exhibited by a novel series of 6-desfluoroquinolones and some classic quinolones on pentylenetetrazole (PTZ)-induced seizures in mice were evaluated and compared. Animals were intraperitoneally injected with vehicle or quinolone derivatives (5 to 100 μg/g of body weight) 30 min before the subcutaneous (s.c.) administration of PTZ (40 μg/g). In each experiment, mice were then observed for 1 h to monitor for the incidence and onset of clonic seizures. The order of proconvulsant activity in our epileptic model was MF5184 > MF5187 > pefloxacin > MF5189 > ofloxacin > ciprofloxacin > MF5140 > MF5181 > MF5137 > rufloxacin > MF5143 > MF5158 > MF5191…
Background Mefloquine can cross the blood–brain barrier and block the gap junction intercellular communication in the brain. Enhanced electrical coupling mediated by gap junctions is an underlying mechanism involved in the generation and maintenance of seizures. For this reason, the aim of this study was to analyze the effects of the systemic administration of mefloquine on tonic-clonic seizures induced by two acute models such as pentylenetetrazole and maximal electroshock. Results All the control rats presented generalized tonic-clonic seizures after the administration of pentylenetetrazole. However, the incidence of seizures induced by pentylenetetrazole significantly decreased in the groups administered systematically with 40 and 80 mg/kg of mefloquine. In the control group, none of the rats survived after the generalized tonic-clonic seizures induced by pentylenetetrazole, but survival was improved by mefloquine. Besides, mefloquine significantly modified the total spectral power as well as the duration, amplitude and frequency of the epileptiform activity induced by pentylenetetrazole. For the maximal electroshock model, mefloquine did not change the occurrence of tonic hindlimb extension. However, this gap junction blocker significantly decreased the duration of the tonic hindlimb extension induced by the acute electroshock. Conclusions These data suggest that mefloquine at low doses might be eliciting some anticonvulsant effects when is systemically administered to rats.
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This study was designed to investigate the involvement of opioidergic/nitrergic systems in the anticonvulsant effect of mefloquine, compared with chloroquine, in mice. Seizures were induced by pentylenetetrazol and maximal electroshock. Mice were randomly subjected to receive mefloquine or chloroquine thirty minutes in advance. The role of opioidergic/nitrergic systems was shown by co‑administration of pharmacological intervention and nitrite levels measurement in mice hippocampi. Results indicated that mefloquine (40 mg/kg) and chloroquine (5 mg/kg) significantly decreased the occurrence of tonic hindlimb extension. Also, mefloquine 120 mg/kg and chloroquine 5 mg/kg significantly increased seizure latency and decreased mortality rate. Mefloquine decreased seizure frequency too. Besides, mefloquine (20 mg/kg) and chloroquine (5, 10 mg/kg) significantly increased seizure threshold. Interestingly, L‑NAME, 7‑NI and naltrexone pre‑treatment reversed the anticonvulsant effects of both me...
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EFFECT OF FLUPIRTINE ON SEIZURE ACTIVITY AND ITS INTERACTIONS WITH ANTIEPILEPTIC DRUGS IN RATS.
Aims:-To evaluate the effect of flupirtine in maximal electroshock seizures (MES) induced seizures in rats and study the interactions of flupirtine with some antiepileptic drugs, by using subtherapeutic doses. Methods and Material:-The effects were assessed by methods of MES. Results:-Flupirtine alone showed protection against electroshock seizures. Combined treatment of flupirtine and antiepileptic drugs exerted a much stronger protective effect against electroshock seizures than either drug alone or addition of their effect. This was highly significant for a combination of flupirtine with diazepam, sodium valproate, phenobarbitone, and phenytoin. Conclusions:-Flupirtine has anticonvulsant activity and has synergistic activity with antiepileptic drugs in MES model. Extrapolation of these combinations in clinical practice may suggest its utility in grandmal epilepsy as add-on drug.