Analysis of the Meningiomas’ Hormonal Profile in Patients with Meningioma and Breast Cancer (original) (raw)
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Correlations of female steroid hormone receptors with histologic features in meningiomas
Acta Neurochirurgica, 1991
A series of 39 samples were obtained from meningiomas in 28 patients in order to investigate the relationships of the oestrogen receptor (OER) and progesterone receptor (PR) with the tumoural subtype and some histological features. Twenty-one samples were positive (> 10 fmole/mg protein), 7 were OER-PR-negative, and 1 was positive in both receptors. Twenty-two samples were considered as syncitial, 7 transitional, 7 fibroblastic and 3 angioblastic. The histological subtype was not found to be significantly related to the presence or absence of PR. Relations were not observed between the progestin receptor and the following histological parametrs: cellular pattern, cell density, nuclear polymorphism, mitosis, lymphoplasmacellular infiltrates, degree of vascularization, psammoma bodies and interstitial fibrosis. Only the presence of intratumoural necrosis was significantly related with a low PR levels. However, progesterone binding activity was lower in tumours with numerous psammomas, fibroblastic cell pattern and interstitial fibrosis. The clinical and biological significance of these results is discussed.
Steroid receptors in meningiomas
Arquivos de Neuro-Psiquiatria, 1985
Cytosolic estrogen (ER), progesterone (PR), androgen (AR) and glucocorticoid receptors (GR) were evaluated in 10 meningiomas using a dextran charcoal coated method. We consider as positive specific receptor values >10fMol/mg protein. In this study 20% of the meningiomas contained very low titers of specific ER. PR was detectable in 90% of the tumors, at high levels. The mean PR content of PR+ tumors was 60±38fMol/mg prot. GR and AR were present in moderate levels, in 70% of the tumors. Competition studies demonstrated steroid specificity for these hormone-binding proteins. Female patients have a higher receptor incidence and titer. In conclusion, it can be hypothesized that the meningioma are a target tissue for steroids and that endocrine therapy may be relevant to unoperable and/or reccurent tumors.
IP innovative publication pvt. ltd, 2019
Introduction: Meningiomas are mostly benign tumour and major prognostic factor for recurrence is mostly dependent on the histopathological category, proliferation indices, grading and estrogen (ER) and progesterone (PR) receptor status. The present study was undertaken to find ER, PR receptor in excised specimen of meningioma and its correlation with Ki67 labelling index. Materials and Methods: 75 cases of meningioma collected over period of 2 years was subjected to Haematoxylin and Eosin staining for routine histopathological investigation and immunohistochemical staining against PR, ER and Ki-67 by means of mouse monoclonal antibodies. Ki-67 labelling index was determined and Histological grade, PR, ER receptor status was evaluated. Results: The Mean Ki-67 LI was significantly higher in PR-negative versus PR-positive meningioma, Grade II versus Grade I and males versus females. Whereas the PR positivity was significantly higher in Grade I versus Grade II and females versus males. A strong converse relationship was established between PR expression and Ki-67 LI. Conclusions: As per the results it has been revealed that immnodetection of ki-67 LI and PR expressions in meningiomas are the important indicators for assessing prognosis and recurrence rate in meningioms.
Progesterone and estrogen receptors: opposing prognostic indicators in meningiomas
Journal of Neurosurgery, 2006
Object The preponderance of progesterone receptors (PRs) and the scarcity of estrogen receptors (ERs) in meningiomas are well known. The expression of PRs may relate to tumor grade and recurrence. Cytogenetic abnormalities are associated with aggressive behavior, recurrence, and progression. In this study, the authors focus on the prognostic implications of hormone receptors in meningiomas to help determine the clinical and biological aggressiveness of tumors and their correlations with cytogenetic abnormalities. Methods Two hundred thirty-nine patients with meningiomas were separated into three groups. Group 1 (PR-positive group) comprised patients whose meningiomas displayed expression of PRs alone. Group 2 (receptor-negative group) included patients whose lesions did not have receptors for either progesterone or estrogen. Group 3 (ER-positive group) included patients whose tumors displayed expression of ERs. Clinical and histological findings, proliferative indices, tumor recurre...
Estrogen and progesterone in meningioma: Bridging the gap of knowledge
Neurology Asia, 2023
Meningiomas are primary central nervous system tumor with the highest prevalence. Meningiomas have a high recurrence rate in the same location. One of the factors thought to be associated with the frequency of meningiomas is hormonal status. However, research on this subject is still controversial. This review aims to discuss the effect of sex hormones on meningiomas. Sex hormones, especially progesterone, have been shown to play a role in tumorigenesis and meningioma recurrence. Progesterone receptors also play a role in meningioma recurrence where a low number of receptors indicates a poor prognosis. However, the molecular relationship between meningiomas at low progesterone receptor expression is still unknown. Further research is still needed to determine the role of sex hormones, especially progesterone, and their receptors, in both tumorigenesis and meningioma progression. This research ensures that new science in the field of endocrinology can be utilized for both primary preventive, secondary preventive, and therapeutic strategies for meningiomas.
Progesterone Receptor Expression in Meningiomas: Pathological and Prognostic Implications
Frontiers in Oncology
BackgroundThe progesterone receptor (PR) is variably expressed in most meningiomas and was found to have prognostic significance. However, the correlation with patient age, tumor location, time to recurrence, and pattern of regrowth has scarcely been discussed.MethodsA surgical series of 300 patients with meningiomas is reviewed. The PR expression was classified as: 0. absent; 1. low (<15%); 2. moderately low (16–50%); 3. moderately high (51–79%); 4. high (≥80%). The PR values were correlated with the patient age and sex, meningioma location, WHO grade, Ki-67 MIB1, recurrence rate, pattern of recurrence (local-peripheral versus multicentric diffuse), and time to recurrence.ResultsThe PR expression has shown lower rate of high expression in the elderly group (p = 0.032) and no sex difference (including premenopausal versus postmenopausal women), higher expression in medial skull base and spinal versus other locations (p = 0.0036), inverse correlation with WHO grade and Ki67-MIB1 (...
Expression of progesterone receptors in meningioma patients: serial case
2020
Meningioma is a tumor that arises from the meningothelial cells of the arachnoid membranes which are attached to the dura mater. Meningioma is one of the most common tumors found in people and occurs more commonly in women due to the link with the progesterone hormones. The risk of developing meningiomas is increased in patients who are exposed to exogenous progesterone such as hormonal contraceptives. This case report must be reported because the hormonal contraceptives are largely used in Indonesia and it is important to report this case. It is reported in three cases of female patients aged 58 years, 46 years, and 38 years with the main complaint of chronic progressive headache and decreased consciousness with left hemiparesis. All patients had a history of using hormonal contraceptives for more than four years. Head CT scans were carried out and obtained the results of extra-axial masses in the supratentorial region of all three patients. Therapeutic management was performed by ...