Creatine Supplementation Exhibits Sex Differences in White Adipose Tissue and Increases Mitochondrial Markers in Female Rats (original) (raw)

The FASEB Journal, 2020

Abstract

Activation of white adipose tissue (WAT) thermogenesis, known as WAT browning, has emerged as an attractive approach to treat obesity and obesity‐related diseases. Traditionally BAT or browning WAT has been defined by the expression of uncoupling protein 1 (UCP1), a mitochondrial protein that uncouples respiration from ATP production. However, recent work has highlighted creatine metabolism or futile cycling as a potential thermogenic pathway. Creatine‐driven futile cycling is a catabolic process which results in ATP oxidation by mitochondrial creatine kinase, resulting in the phosphorylation of creatine and increases in ADP concentrations that drive thermogenic respiration. The purpose of the present study was two‐fold: 1) to determine the effects of creatine supplementation on markers of WAT browning, and 2) to determine if creatine supplementation exhibits sex differences. Thirty‐two Sprague‐Dawley rats (16 male, 16 female) were randomly assigned to one of four experimental group...

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