Hepatitis B virus infection and associated factors among antenatal care attendees in Dessie City Administration, North-East Ethiopia: a case-control study (original) (raw)
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Pan African Medical Journal, 2020
Introduction: globally, approximately 350-400 million persons are chronically infected with hepatitis B virus (HBV), over 65 million of whom are in Africa. One in four people with chronic hepatitis B develop serious health problems. Mother-to-child transmission (MTCT) is responsible for more than half of chronic infections. If infected at birth, a child has a 90% chance of becoming a chronic carrier. We evaluated hepatitis B virus prevalence and risk factors for infection among pregnant women attending antenatal clinics in West Hararghe public hospitals, Oromia region, Ethiopia. Methods: we conducted a cross-sectional study among 363 pregnant women at routine antenatal clinic visits in West Hararghe public hospitals from April-May, 2017. We used systematic random sampling method to enroll participants. We used a structured questionnaire to collect information on risk factors, and collected blood samples to test for hepatitis B Virus surface antigen (HBsAg) by enzyme-linked immunosorbent assay (ELISA). Data were entered using EpiData Version.3.1 and exported to SPSS Version 23.0 for descriptive analyses and binary logistic regression Results: the overall seroprevalence of HBsAg among participants was 6.1% (95% CI 3.9-8.5). History of abortion (aOR=4.3, 95% CI 1.3-15.0), traditional tonsillectomy (tonsillectomy conducted by an untrained practitioner) (aOR=4.4, 95% CI 1.1-17.8), admission to a health facility (aOR=4.4, 95% CI 1.2-16.9), multiple sexual partners (aOR=6.3, 95% CI 1.7-23.4) and familial liver disease (aOR=8.2, 95% CI 2.1-32.8) were associated with hepatitis B virus infection among pregnant women. Conclusion: the prevalence of hepatitis B virus in study area indicates a high-intermediate level epidemic. Multiple types of healthcare, as well classic risk factors such as multiple sex partners and a family history of liver disease increas ed the odds of infection. Hygiene promotion and infection prevention methods in healthcare settings are recommended to avoid nosocomial infections. To reduce MTCT, we recommended screening all pregnant women for hepatitis B virus as part of routine antenatal care and supportive treatment and making available methods of preventing infection at birth, including prophylaxis and birth dose vaccine.
Background: Hepatitis B infection is one of the world's most serious public health problems, causing significant morbidity and mortality. More than 2 billion individuals around the world have been infected with the hepatitis B virus (HBV), and approximately 400 million people are chronically infected with the virus, with more than a million dying each year from hepatitis B virus-related liver disease. A newborn infant whose mother is positive for both HBsAg and HBeAg has a 90% chance of developing chronic infection by the age of 6. Its infectivity is a 100 times that of the human immunodeficiency virus, but it receives little attention in public health. Therefore, this study was conducted to assess the prevalence of hepatitis B infection and its associated factors among pregnant mothers attending antenatal care at public hospitals in west Hararghe, eastern Ethiopia 2020. Method: This institution-based cross-sectional study was conducted on 300 pregnant mothers selected by systematic random sampling from September to December 2020. Data were collected by face-to-face interview using a pretested structured questionnaire. A blood sample was collected and tested for hepatitis B surface antigen using the enzyme-linked immunosorbent assay test method. Data were entered into EpiData version 3.1 and exported to Statistical Package for the Social Science version 22 for analysis. Bivariate and multivariable logistic regressions were used to assess the association between outcome and predictor variables. P-value <0.05 was considered to be statistically significant. Results: The overall seroprevalence of hepatitis B virus infection was 8% [95% confidence interval (CI): 5.3-11.0] among pregnant mothers. History of tonsillectomy [adjusted odd ratio (AOR) = 5.7; 95% CI: 1.3-23.9], tattoo (AOR = 4.3; 95% CI: 1.1, 17.0), having multiple sexual partners (AOR = 10.8; 95% CI: 2.5, 45.9), and history of contact with jaundiced patients (AOR = 5.6; 95% CI: 1.2, 25.7) were factors associated with the seroprevalence of hepatitis B virus infection among pregnant mothers.
Background: Hepatitis B is a global public health problem and a major cause of liver disease, including chronic hepatitis, cirrhosis and liver cancer. Pregnant women with hepatitis B virus infection are reservoir for the virus and do have high potential to transmit it to their fetuses and newborns. The objective of the study was to investigatesero-prevalence of hepatitis B surface antigen and assesses risk factors among pregnant women in Ethiopia. Methods: Institution based cross-sectional study was conducted from July to September, 2014 among pregnant women in Ethiopia. A pretested structured questionnaire was employed to collect data on socio-demographic and potential risk factors for HBV infection. Blood sample was collected and tested for the presence of hepatitis B surface antigen using Enzyme Linked Immunosorbent Assay kit. Obtained data were evaluated by frequency, logistic regression analyses, and a significance level of 5 % (α = 0.05) was established. Result: Of the total pregnant women, 11(5.4%) of the study participants were positive for HBsAg. Majority (40.1%) of participants were in age group 25-29 years. The prevalence of HBV infection was higher above 20 years of age. Our finding revealed that none of the study participants were aware of their HBV sero-status. Sero positivity for hepatitis B surface antigen was statistically associated with history of abortion (AOR: 6; 95% CI :(1.39-27.69); P-value: 0.017), surgery (AOR: 5;95% CI: 1.04-24.31; P-value: 0.045) and family history for hepatitis (AOR: 11; 95% CI (1.63 80.44); P-value: 0.014). Conclusion: According to the research findings, there was an intermediate endemicity of hepatitis B virus infection. The finding revealed that history of abortion, surgery and family history for hepatitis were the major risk factors for the high prevalence of hepatitis B infection in the study area. Appropriate, targeted and timely response is mandatory for tackling the harmful health effects of HBV infection/disease.
Background: Hepatitis B infection is among the most common public health concerns globally, particularly in low-and middle-income countries. The prevalence of hepatitis B infection is more common among most vulnerable populations, including pregnant women. However, there are limited studies on hepatitis B virus infection among pregnant women in low-income countries, including Ethiopia, and the previous studies focused on the general population rather than the pregnant women. The purpose of this study was to estimate the prevalence and examine factors associated with hepatitis B virus infection among pregnant women in the Northern Ethiopia. Methods: nstitution-based cross-sectional study design and a structured face-to-face interview were used to collect data from the study participants. Simple random sampling method was used to select eligible study participants. Data were entered using EpiData version 3.1, and SPSS version 20 was used for the data analysis. We analyzed the data to examine factors associated with hepatitis B virus infection using binary and multivariable logistic regression models. Results: The overall prevalence of hepatitis B virus infection among the study participants was 9.2%. The majority (46.7%) of the study participants infected by hepatitis B were in the age group 25-34 years. The study found that married study participants were more likely to be infected by hepatitis B when compared to the unmarried study participants. Having history of abortion [OR = 0.12 (95% CI: 0.03, 0.47), P < 0.01] and having history of tattooing [OR = 0.21 (95% CI: 0.07, 0.62), P < 0.01] were found to be statistically significantly associated with the prevalence of hepatitis B virus infection among pregnant women. Conclusion: A significant number of pregnant women participating in the study were infected by the hepatitis B virus which needs efficient intervention to reduce the infection rate. Further, educational status, having history of surgery, dental procedure, ear piercing, abortion and tattooing were found statistically to be significant before controlling for confounders. But, after controlling for confounders, only having history of tattooing and having history of abortion were found to be independent factors affecting the prevalence of the infection.
American Journal of Health Research, 2020
Background: Hepatitis B virus infection is one of the serious public health problems in the world particularly in a developing country. It is transmitted from person to person by anybody fluid commonly through sexual intercourse. Hepatitis B virus infection has serious effects on both pregnant women and infants. Objective: This study aims to assess the magnitude of Hepatitis B virus infection and associated factors among pregnant women attending antenatal care service in Bishoftu town. Methods: A cross-sectional study was conducted involving a total of 276 pregnant women attending antenatal care service at Bishoftu town from July 17-August 17, 2019. A systematic random sampling technique was used to select the study subjects. A blood sample was drawn from each study subject to testing for Hepatitis B surface antigen and confirmation for positive results was done by an enzyme-linked immune sorbent assay. Completed data from questionnaires were entered into Epi info version 7 and, exported and analyzed by SPSS Version 21. Descriptive statistics were carried out to estimate the characteristics of the participants. Bivariate and multivariate logistic regression analyses were used to identify factors associated with Hepatitis B virus infection. Odds ratios at 95% confidence interval were calculated. P-value < 0.05 was considered as a significant. Result: The magnitude of Hepatitis B virus infection among pregnant women attending antenatal care services in Bishoftu town was 18 (6.5%). Study subject with the previous history of the dental procedure [AOR=4.79, 95%CI (1.41-16.23)], body tattooing [AOR=3.18, 95%CI (1.01-10.03)] and those with a multi-sexual partner [AOR=5.19, 95%CI (1.09-24.60)] were known to have a significant association with Hepatitis B virus infection. Conclusion and Recommendation: This study indicates that Bishoftu town has intermediate endemicity of Hepatitis B virus infection among pregnant women. Regarding the risk factors, pregnant women with a dental procedure, body tattooing, and multi-sexual partner were found to be at risk of Hepatitis B virus infection. To minimize the higher risk exposure status of mothers, increasing awareness and public health education on the mode of Hepatitis B virus transmission, high-risk behaviors and methods of prevention are recommended.
Clinical Epidemiology and Global Health
Background: Hepatitis B virus is the most common major hepatic infection. During pregnancy, the hepatitis B virus has an elevated rate of vertical transmission. Fetal hepatitis acquired during pregnancy leading to an impairment of cognitive and physical development in the future lives of children. Purpose: This study was to assess the prevalence of the hepatitis B virus and its associated factors among pregnant women receiving antenatal care at public health facilities in Ambo town, Central Ethiopia, 2019. Materials and methods: A cross-sectional facility-based study was conducted among 361 systematically selected pregnant women who received antenatal care from March 25 and May 10, 2019. Data were gathered through face-to-face interviews and blood samples were taken. The data has been cleaned and checked, entered into Epi Data 3.1, and exported into SPSS version 25 for further analysis. Bivariable and multiple logistic regressions were used. The level of statistical significance was reported to be < 0.05. Results: Prevalence of hepatitis B virus infection was 4.99%. Admission history (AOR = 5.55, 955CI:(1.06, 29.03)], had history tattoo [AOR = 5.31, 95%: CI (1.45, 19.44)], having multiple sexual partners (AOR = 7.22, 95%CI:(1.47, 35.45)], drinking alcohols [AOR = 7.97, 95% CI:(2.39, 26.52)], had history of abortion (AOR = 6.303, 95%CI:(1.45, 27.39) and had history of contact with liver disease person (AOR = 20.64, 95% CI:(2.23, 19.82)] were factors significantly associated with Hepatitis B virus infection. Conclusions: In this study, the prevalence of the hepatitis B virus was intermediate. Having an admission history, tattoo, multiple sexual partners, drinking alcohol, having a history of abortion, and a having history of contact with family had liver diseases were should be prioritized for interventions aiming at addressing Hepatitis B virus among pregnant women.
Hepatitis Research and Treatment, 2016
Hepatitis B virus (HBV) is a serious cause of liver disease affecting millions of people throughout the world. When HBV is acquired during pregnancy, prenatal transmission can occur to the fetus. Therefore, this study is aimed at estimating seroprevalence and associated factors of HBV infection among pregnant women attending Antenatal Clinic (ANC) of Arba Minch Hospital, Southern Ethiopia. A facility based cross-sectional study was conducted on 232 pregnant women visiting ANC from February to April, 2015. Data regarding sociodemographic and associated factors were gathered using questionnaire. Serum samples were tested for hepatitis B surface antigen (HBsAg) by Enzyme Linked Immunosorbent Assay. Data was analyzed using SPSS version 20. The overall seroprevalence of HBV infection was 4.3% (95% CI: 2.2–6.9%). Multivariate analysis showed that history of abortion (AOR = 7.775; 95% CI: 1.538–39.301) and having multiple sexual partners (AOR = 7.189; 95% CI: 1.039–49.755) were independent...
Research Square (Research Square), 2024
Hepatitis B virus (HBV) infection is one of the most common health problems worldwide and is associated with high mortality and heavy economic burdens. The aim of this study was to determine the prevalence of hepatitis B surface antigen (HBsAg) and associated risk factors among pregnant women attending antenatal clinics in Adigrat General Hospital in Northern Ethiopia. METHODS An institutional-based cross-sectional study was conducted from January to March, 2024, among 385 pregnant women. Participants were selected through a systematic random sampling method. Sociodemographic and associated factor data were collected using a structured questionnaire, and 5 mL blood samples were collected. The data were subsequently entered into EPI Info and analyzed using SPSS version 25. Descriptive statistics were computed. Bivariate and multivariate regression analyses were employed to measure associations, and values < 0.05 were considered to indicate statistical signi cance. RESULTS The overall seroprevalence of HBsAg among the 385 study subjects enrolled was 10.4% (n = 40). HBsAg was common in all age groups. The prevalence of infection was greater in those who had a history of multiple sexual partners (22.7%), early piercing (13.4%), or abortion (27.6%), as was the history of delivery (26.3%) and genital mutilation (35.7%). According to multivariate logistic regression, patients
PLOS ONE, 2016
Background Hepatitis B virus (HBV) infection is a serious public health problem worldwide. Reports have shown that 68,600 people die of HBV infection and more than 300,000 deaths due to liver cancer secondary to hepatitis B every year globally. Women who are infected with HBV can vertically transmit the infection to their infants. This study aims to determine the prevalence of HBV infection and associated factors among pregnant women. Methods and Findings A hospital-based cross-sectional study was conducted among pregnant women who attended antenatal care clinic (ANC) for routine pregnancy checkup between 18 March 2015 and 15 May 2015. Data were collected by face to face interview using a pre-tested questionnaire. Serum was withdrawn for each study subject and used to test for Hepatitis B Surface Antigen (HBsAg) by an enzyme linked immunosorbent assay (ELISA) test kit. Binary logistic regression analysis was used to examine the association between explanatory variables and outcome variable. The prevalence of HBV infection was found to be 6.
Research Square (Research Square), 2019
Background; Hepatitis B virus (HBV) is the world's most common and highly contagious liver infection. Its transmission methods are: mother to child, via open wounds, sexual contact, blood transfusion and other blood contact related activities. Prevalence of HBV among pregnant women in Africa ranges from 3.67-16.5% and in Ethiopia 2.4 to 8.4%. Hepatitis B infection leads to high morbidity and mortality for mother as well as for their infants due to the vertical transmission. Hence assessing the prevalence and associated factors of Hepatitis B Virus infection is a priority. Methodology : An institution based cross sectional study was conducted with a total of 194 of pregnant women attending antenatal care at Agena health center from May 1-30/2019. Frequency analysis and Logistic regression test was used to determine the associated factors associated with Hepatitis B virus by using SPSS version 25. Results: The prevalence of HBV in Agena health center among pregnant women were 4.1% and it was associated with marital status, history of hospital admission and history of abortion. Conclusion : The prevalence of HBV in Agena health center among pregnant women was intermediate. Since routine screening and immunization of all pregnant women is mandatory.