A Metabolomic Approach for Screening of Acute Liver Failure Patients in Hepatitis E Virus Infection (original) (raw)
Background: Hepatitis E is mainly an acute and self-limiting disease which is endemic to resource poor regions of the world. Some patients have an increased susceptibility to develop fulminant hepatitis which is a rare disorder with high mortality and resource cost. In this study, a metabonomic approach was used to investigate the biochemical perturbation of the serum samples from acute liver failure patients induced by hepatitis E virus. Materials and Methods: Serum samples from hepatitis E virus-related acute liver failure patients (n = 20) and healthy controls (n = 20) were studied. Gas chromatography–mass spectrometry technique integrated with a commercial mass spectral library for the peak identification was used to detect the serum metabonome. Results: Out of the 24 metabolites detected, the serum levels of benzenepropanoic acid, lactic acid, hexadecanoic acid, L-proline, serine, and butanoic acid were significantly higher in the acute liver failure patients than those in the ...
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