Design of novel nicotinic ligands through 3D database searching (original) (raw)

Bioorganic & Medicinal Chemistry, 2005

Abstract

A series of quinoline derivatives have been designed on the basis of results from a 3D search of the Cambridge Structural Database using the nicotinic pharmacophore as a query and further modified using molecular modeling. Some of the synthesized compounds show nanomolar affinity for the central nicotinic receptor on rat cerebral cortex.

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