PATHOPHYSIOLOGY OF SARS -nCoV-2: STRUCTURE, MODE OF INFECTION AND POSSIBLE TREATMENTS (original) (raw)

PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY

Abstract

Rapid advancement in technology had made the smooth survival of the human race in this 21st century. Besides these serious global disastrous diseases, hazards often emerged out. The human race has faced a serious health emergency due to the emergence of coronavirus first recognized in 2019 which is characterized by pneumonia, lymphopenia, dead lymphocytes, and a cytokine gust or infusion reaction. SARS-CoV-2 belongs to the Coronaviridae family, a family of pleomorphic ss (+) RNA viruses. Its genome is associated with the N protein forming the nucleocapsid, coated with a spike glycoprotein-adorned membrane. it is reported that COVID-19 is primarily transmitted human-to-human via oral and respiratory aerosols and droplets with the virus-contaminated environment play a lesser role in the propagation of disease. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is rapidly spreading worldwide, and WHO declared the outbreak of this disease a pandemic on March 11, 2020.Before cu...

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