Synthesis and molecular crystal of 3-Chloro-2-(1-chloro-1-methyl-ethyl)-2,3-dihydro-1H-naphtho[2,1-b]oxepin-4-one (original) (raw)

This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Highlights of Paper 1. The first example of chlorine substituted 7-member benzoxepinones is presented in the paper. 2. The favoured 8-endo-trig radical cyclization protocol predominated by a 7-exo-trig radical cyclization for the synthesis of targeted molecule. 3. CuCl/TMEDA-promoted halogen atom transfer radical cyclization (HATRC) reaction protocole is used for the synthesis of 7-member benzolactone: 3-Chloro-2-(1-chloro-1methyl-ethyl)-2,3-dihydro-1H-naphtho[2,1-b]oxepin-4-one. 4. A hindered substituted alkene dichloro-acetic acid 1-(3-methyl-but-2-enyl)-naphthalen-2yl ester synthesized. 5. The benzoxepinones related molecules are active for anti-fungal, anti-tumour and antiinflammatory activities and are also active for cytotoxicity against human KB cells. 6. The structure of the Lactone was confirmed by X-ray diffraction data.