Association of Radiological Features with Histological Features in Patients with Renal Cell Carcinoma: A Cross-sectional Study (original) (raw)
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Renal cell carcinoma: histological classification and correlation with imaging findings
Radiologia Brasileira, 2015
Renal cell carcinoma (RCC) is the seventh most common histological type of cancer in the Western world and has shown a sustained increase in its prevalence. The histological classification of RCCs is of utmost importance, considering the significant prognostic and therapeutic implications of its histological subtypes. Imaging methods play an outstanding role in the diagnosis, staging and follow-up of RCC. Clear cell, papillary and chromophobe are the most common histological subtypes of RCC, and their preoperative radiological characterization, either followed or not by confirmatory percutaneous biopsy, may be particularly useful in cases of poor surgical condition, metastatic disease, central mass in a solitary kidney, and in patients eligible for molecular targeted therapy. New strategies recently developed for treating renal cancer, such as cryo and radiofrequency ablation, molecularly targeted therapy and active surveillance also require appropriate preoperative characterization of renal masses. Less common histological types, although sharing nonspecific imaging features, may be suspected on the basis of clinical and epidemiological data. The present study is aimed at reviewing the main clinical and imaging findings of histological RCC subtypes.
RENAL CELL CARCINOMA: MRI AND HISTOPATHOLOGICAL SUBTYPE CORRELATION
National Journal of Medical Research, 2016
Introduction: Renal cell carcinoma (RCC) is the most common malignant tumor involving the kidney. Approximately 40% of patients with RCC eventually die from progression of this disease, making it the most lethal urologic malignancy. Determining the subtypes of RCC is among major goal in preoperative radiological work up in further management. MRI has advantages of having inherent soft tissue contrast, detection of blood and lipid products and excellent sensitivity to detect small amounts of intravenous contrast. Methodology: In this article, study of histopathological and MRI imaging features of various subtypes of RCC is discussed emphasizing role of MRI in characterization and presurgical staging of renal masses. Results: MRI is particularly helpful in evaluating small lesions which cannot be studied by Ultrasonography (USG) or Computed tomography (CT). Percutaneous biopsy is a minimally invasive method to diagnose renal tumors with accuracy upto 70 to 90%. Apart from diagnosing lesions, MRI along with histopathological subtype is very crucial to decide severity and prognosis of RCC and to guide treatment protocol. Conclusion: RCC is divided into various subtypes according to histopathological examination like clear cell, papillary, collecting duct, chromophobe, multilocular cystic and unclassified variety. Accurate characterization of renal masses is essential to ensure appropriate case management and to assist in staging and prognosis.
International Journal Of Community Medicine And Public Health, 2020
Background: Renal cell carcinoma (RCC) is associated with highest mortality rates of all the genitourinary tumors with increased incidence in the past few decades. It is heterogenous tumor with several histological types. Main diagnostic approach is radiological imaging followed by histopathology.Methods: It is a retrospective study conducted at a tertiary care cancer hospital in Pakistan. We reviewed the record of all the RCC patients in terms of age, gender, radiological manifestation of tumor size, polarity, laterality, stage including nodal status, metastasis and histological type.Results: Our study included 149 patients of RCC. Mean age of presentation was 57 years with a male predominance. The most common stage of presentation was stage 3 seen in 41% patients followed by stage 1 in 37% patients. nodal metastasis was observed in around 13% patients and distant metastasis in 8% patients. Also, majority of the patient had histological subtype of clear cell CA (63%) followed by pa...
Pakistan Journal of Health Sciences, 2023
Renal cell carcinoma (RCC) comprises for between 90-95% of renal malignancies, is the sixth most common cancer in men and tenth in women [1]. In developed nations, where incidence rates are higher and up to half of cases discovered incidentally [2]. Due to the widespread use of abdominal imaging for a variety of renal speci c and nonspeci c complaints, the incidental identi cation of renal masses has signi cantly increased over time [3]. According to current estimates, accidental detection accounts for more than half of all kidney masses [4, 5]. The majority of renal mass lesions were once considered to be cancerous, while benign lesions like oncocytoma(3-5%), a n g i o m y o l i p o m a (0. 7-2 %) , a n d m e t a n e p h r i c adenoma(0.1%) were believed to occur just as commonly in
Ramathibodi Medical Journal, 2020
Background: The increased use of imaging modalities has led to a greater incidence in depicting solid renal mass. These lesions comprise a wide spectrum of malignant such as renal cell carcinoma (RCC) and benign histologies. Objective: To determine the multidetector computed tomography (MDCT) features that discriminate RCC from other focal renal lesions. Methods: A retrospective review was performed on 148 patients who underwent renal CT scan followed by renal surgery or biopsy during January 2008 to July 2014. Specific predictive MDCT features of RCC were determined by logistic regression analysis. Interobserver agreement (kappa [κ] values) was also calculated for each CT feature. Results: In 148 pathologic proved focal renal lesions, 91 (61.5%) were RCCs and 57 (38.5%) were non-RCCs. RCCs were more likely to be in male patients (OR, 5.39; 95% CI, 2.25-12.90), no internal fat component (OR, 46.50; 95% CI, 5.25-411.90), locate at peripheral (OR, 7.41; 95% CI, 1.63-33.73), and mixed central-peripheral locations (OR, 26.22; 95% CI, 4.23-162.58) of the kidney. There was moderate-to-excellent agreement among the readers over all these features (κ = 0.43-0.91). Conclusions: Focal renal lesion with no internal fat component in MDCT is the most useful characteristic in differentiating RCCs from others.
Correlation between size of renal cell carcinoma and its grade, stage, and histological subtype
Urology journal, 2007
The aim of this study was to determine the correlation between histological subtype, size, grade, and stage of the kidney tumors and to investigate whether a correlation exists between the size of the kidney tumor and its behavior. Between 1996 and 2004, we had 212 patients with radical or partial nephrectomy due to a kidney tumor at Shaheed Labbafinejad Medical Center. Their pathologic blocks were re-evaluated with consideration of their tumor size and pathologic features. Of 212 pathologic blocks, 17 (8%) were benign and 195 (92%) were malignant masses including 179 renal cell carcinoma (RCC) tumors. Malignant tumors were slightly greater compared with the benign ones (P=.10). There was no significant relation between the size of tumor and the histological subtype. Significant relations between the size of the kidney tumor and the nuclear grade (P=.007), clinical symptoms (P=.02), and extracapsular extension (P<.001) were observed. In smaller RCC tumors (< 4 cm), extracapsul...
Journal of clinical imaging science, 2016
The objective of this study was to define the characteristic imaging appearances of the common renal cell carcinoma (RCC) subtypes. The Institutional Review Board approval was obtained for this HIPAA-compliant retrospective study, and informed consent was waived. 520 patients (336 men, 184 women; age range, 22-88 years) underwent preoperative cross-sectional imaging of 544 RCCs from 2008 to 2013. The imaging appearances of the RCCs and clinical information were reviewed. Data analysis was performed using parametric and nonparametric statistics, descriptive statistics, and receiver operating characteristic analysis. The RCC subtypes showed significant differences (P < 0.001) in several imaging parameters such as tumor margins, tumor consistency, tumor homogeneity, the presence of a central stellate scar, T2 signal intensity, and the degree of tumor enhancement. Low T2 signal intensity on magnetic resonance imaging (MRI) allowed differentiation of papillary RCC from clear cell and ...