Investigation of antitumor effects of Lactobacillus crispatus in experimental model of breast cancer in BALB/c mice (original) (raw)

Immunotherapy, 2018

Abstract

To evaluate the effect of intraperitoneal injections of heat-killed Lactobacillus crispatus on breast tumor size and overall survival of Balb/c mouse received 4T1 mammary carcinoma. Materials and methods: Different doses of L. crispatus have been injected intraperitoneally in BALB/c mice. Tumor size was decreased in the experiment group treated with 1 × 10bacteria/200 μl. Treatment with 1 × 10bacteria/200 μl resulted in survival improvement. The myeloid-derived suppressor cells and reactive oxygen species production have been increased in all groups. Cox2 expression decreased in tumor tissues of the mice treated with 10bacteria/200 μl. The expressions of Arginase and iNos increased in the spleen and tumor tissues of those treated with 5 × 10bacteria/200 μl. We have shown the protective effect of L. crispatus on survival of tumor-bearing mice.

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