PO-0821: Radiation-induced late rectal toxicity for IMPT vs VMAT in patients with localized prostate cancer (original) (raw)

An ongoing multicenter observational study investigates the intestinal, hematologic, and urinary toxicity resulting from whole-pelvis radiotherapy (WPRT) in patients undergoing radical, adjuvant, or salvage treatment for prostate cancer. Utilizing the Inflammatory Bowel Disease Questionnaire (IBDQ) for evaluating radiation-induced intestinal toxicity (IT), the study focuses on acute IT associated with different radiotherapy techniques including static-field IMRT, Tomotherapy, and VMAT. Findings reveal that even with modern IMRT, radiation-induced IT remains significant, with symptom rates from 7% to 50%. Techniques influence abdominal pain, cramps, rectal bleeding, and nausea, while social and emotional well-being is impacted by bowel symptoms. Additionally, a secondary focus discusses the development of the TRAC tool for improving delineation accuracy in clinical trials.