The Mitochondrial Membrane as a Chemiosmotic Transducer (original) (raw)

Advances in Experimental Medicine and Biology, 1971

Abstract

About 30 years ago it was understood thai the cell membrane had the capacity of translocating Na and K. More recently this property has been related to the utilization of ATP (for a review cf Ref. 1). The conversion of the energy of a chemical compound such as ATP into anion concentration gradient may be defined as a chemiosmotic transduction. It is immediately clear that this is a foundamental property of the plasma membrne. Very recently it has been reported (2) that the Na pump of the red cell could be reversed, i.e. that ATP could be synthsized t the expense of concentration gradients of Na+ and K+. Unfortunately however the experiments gave only a qualitative indication of this reaction since no net synthesis of ATP could be detected.

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