Impaired Cardiac Interoception In Patients With Multiple Sclerosis. (P1.116) (original) (raw)

Neurology, 2015

Abstract

Objective: To evaluate the heartbeat evoked potential (HEP) in patients with multiple sclerosis (MS) and controls. Background: The HEP is a negative modulation between 200 and 400 ms and is associated with the perception of the heartbeat (cardiac interoception). The insular cortex is one of the main areas involved in the processing of bodily signal information and of emotional awareness. Regarding MS, several studies have described atrophy of this area; however, there are no reports about whether interoceptive processing is affected or not in these patients. Methods: Thirty three patients with MS and 40 controls were evaluated with a heartbeat detection (HBD) task during which a high density electroencephalogram (hd-EEG) was registered. The HBD task consisted of one condition where subjects paid attention to an external stimulus (control condition) and a second where they followed their own heartbeats without external help (interoceptive condition). Each condition lasted five minute...

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