Regulation of airway neurogenic inflammation by neutral endopeptidase (original) (raw)

Abstract

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Airway neurogenic inflammation, implicated in chronic inflammatory disorders like asthma, is predominantly mediated by tachykinins from peripheral sensory neurons. This inflammatory response includes plasma protein extravasation and airway smooth muscle contraction. Neutral endopeptidase (NEP) modulates this neurogenic inflammation and may be pivotal in maintaining airway integrity. Reduced NEP activity could exacerbate inflammation, suggesting a potential therapeutic role for NEP enhancement or tachykinin receptor antagonists in treating airway disorders.

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