Metabolic correction: a functional biochemical mechanism against disease--Part 1: concept and historical background (original) (raw)
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Human physiology depends on countless biochemical reactions, numerous of which are co-dependent and interrelated. the speed and level of completion of reactions usually depend on the availability of precursors and enzymes. the enzymatic activity depends on the bioavailability of micronutrient cofactors such as vitamins and minerals. in order to achieve a healthy physiological state, the organism requires that biochemical reactions occur at a controlled rate. to achieve this state it is required that metabolic reactions reach what can be considered an optimal metabolic equilibrium. a combination of genetic makeup, dietary patterns, trauma, disease, toxins, medications, and environmental stressors can elevate the demand for the nutrients needed to reach this optimal metabolic equilibrium. in this, part 1, the general concept of metabolic correction is presented with an elaboration explaining how this concept is increasing in importance as we become aware of the presence of genetic variants that affect enzymatic reactions causing metabolic disturbances that themselves favor or promote the disease state. in addition, part 1 reviews how prominent scientists have contributed in fundamental ways to our understanding of the importance of micronutrients in health and disease and in the development of the metabolic correction concept. [P R Health Sci J 2015;34:3-8]
[Metabolic correction: a biochemical option against diseases]
Boletín de la Asociación Médica de Puerto Rico
Human development and its physiology depends on a number of complex biochemical body processes, many of which are interactive and codependent. The speed and the degree in which many physiological reactions are completed depend on enzyme activity, which in turn depends on the bioavailability of co-factors and micronutrients such as vitamins and minerals. To achieve a healthy physiological state, organism need that biochemical reactions occur in a controlled and specific way at a particular speed and level or grade fully completed. To achieve this, is required an optimal metabolic balance. Factors such as, a particular genetic composition, inadequate dietary consumption patterns, traumas, diseases, toxins and environmental stress all of these factors rising demands for nutrients in order to obtain optimal metabolic balance. Metabolic correction is a biochemical and physiological concept that explains how improvements in cellular biochemistry of an organism can help the body achieve me...
Puerto Rico health sciences journal, 2015
A healthy physiology depends on a plethora of complex interdependent biochemical reactions. In order for these reactions to occur suitably, the enzymes and cofactors that regulate their flow must be present in the proper balance. The term metabolic correction is used to describe a biochemical-physiological process that improves cellular biochemistry as a means to an individual's achieving metabolic or physiological optimization. Part 2 discusses how metabolic correction, through the increase of cofactors, can supply unmet enzyme needs and compensate for nutritional deficiencies induced by improper nutritional intake or by the increased demand for nutrients caused by genetics, health conditions, medications, or physical or environmental stressors. Nutrient insufficiencies are causing an increase in morbidity and mortality, at great cost to our society. In summary, metabolic correction improves enzymatic function and satisfies the increasing demand for nutrients. Metabolic correct...
A healthy physiology depends on a plethora of complex interdependent biochemical reactions. In order for these reactions to occur suitably, the enzymes and cofactors that regulate their flow must be present in the proper balance. The term metabolic correction is used to describe a biochemical–physiological process that improves cellular biochemistry as a means to an individual's achieving metabolic or physiological optimization. Part 2 discusses how metabolic correction, through the increase of cofactors, can supply unmet enzyme needs and compensate for nutritional deficiencies induced by improper nutritional intake or by the increased demand for nutrients caused by genetics, health conditions, medications, or physical or environmental stressors. Nutrient insufficiencies are causing an increase in morbidity and mortality, at great cost to our society. In summary, metabolic correction improves enzymatic function and satisfies the increasing demand for nutrients. Metabolic correction can have a significant impact on the reduction of morbidity and mortality and their financial cost to our society and contribute to improving health and well-being. [P R Health Sci J 2015;34:9-13]
Maximum or optimal health requires metabolic harmony. The multiplicity of critical functions of vitamins, minerals and other nutrients at the cellular level, and especially their role as cofactors in enzyme reactions that protect genes from mutations and repair gene damage is probably unrecognized or unappreciated by most health professionals. It can be argued that the true importance of vitamins in human biochemistry is far from fully elucidated, simply due to the high complexity of cellular processes. What is commonly ignored and not fully appreciated is the essential role that various minerals play in human biochemistry. Critical enzymes require such metals as copper, zinc, manganese, selenium, etc. as an integral part of their molecular structure or mechanism of action. Enzymes play a critical role in regulating and orchestrating the rates of the multitude of biochemical reactions that take place in living organisms.
2015
Human physiology depends on countless biochemical reactions, numerous of which are co-dependent and interrelated. the speed and level of completion of reactions usually depend on the availability of precursors and enzymes. t he enzymatic activity depends on the bioavailability of micronutrient cofactors such as vitamins and minerals. in order to achieve a healthy physiological state, the organism requires that biochemical reactions occur at a controlled rate. to achieve this state it is required that metabolic reactions reach what can be considered an optimal metabolic equilibrium. a combination of genetic makeup, dietary patterns, trauma, disease, toxins, medications, and environmental stressors can elevate the demand for the nutrients needed to reach this optimal metabolic equilibrium. in this, part 1, the general concept of metabolic correction is presented with an elaboration explaining how this concept is increasing in importance as we become aware of the presence of genetic va...
Metabolic Correction: A Functional Explanation of Orthomolecular Medicine
Journal of Orthomolecular Medicine
Origin of the Problem Maximum or optimal health requires metabolic harmony. The multiplicity of criti-cal functions of vitamins, minerals and other nutrients at the cellular level, and especially their role as cofactors in enzyme reactions that protect genes from mutations and re-pair gene damage is probably unrecognized or unappreciated by most health profession-als. It can be argued that the true impor-tance of vitamins in human biochemistry is far from fully elucidated, simply due to the high complexity of cellular processes. What is commonly ignored and not fully appreci-ated is the essential role that various min-erals play in human biochemistry. Critical enzymes require such metals as copper, zinc, manganese, selenium, etc. as an integral part of their molecular structure or mechanism of action. Enzymes play a critical role in regulating and orchestrating the rates of the multitude of biochemical reactions that take place in living organisms. Metabolic nutrition is generally r...
The effectiveness of correcting abnormal metabolic profiles
Journal of Inherited Metabolic Disease, 2019
Inborn errors of metabolism cause disease because of accumulation of a metabolite before the blocked step or deficiency of an essential metabolite downstream of the block. Treatments can be directed at reducing the levels of a toxic metabolite or correcting a metabolite deficiency. Many disorders have been treated successfully first in a single patient because we can measure the metabolites and adjust treatment to get them as close as possible to the normal range. Examples are drawn from Komrower's description of treatment of homocystinuria and the author's trials of treatment in bile acid synthesis disorders (3β-hydroxy-Δ 5-C 27-steroid dehydrogenase deficiency and Δ 4-3-oxosteroid 5β-reductase deficiency), neurotransmitter amine disorders (aromatic L-amino acid decarboxylase [AADC] and tyrosine hydroxylase deficiencies), and vitamin B6 disorders (pyridox(am)ine phosphate oxidase deficiency and pyridoxine-dependent epilepsy [ALDH7A1 deficiency]). Sometimes follow-up shows there are milder and more severe forms of the disease and even variable clinical manifestations but by measuring the metabolites we can adjust the treatment to get the metabolites into the normal range. Biochemical measurements are not subject to placebo effects and will also show if the disorder is improving spontaneously. The hypothesis that can then be tested for clinical outcome is whether getting metabolite(s) into a target range leads to an improvement in an outcome parameter such as abnormal liver function tests, hypokinesia, epilepsy control etc. The metabolite-guided approach to treatment is an example of personalized medicine and is a better way of determining efficacy for disorders of variable severity than a randomized controlled clinical trial.