Is inflammation inducing hypoxic tissue modifications in placenta? A retrospective appraisal (original) (raw)

Abstract

Is inflammation inducing hypoxic tissue modifications in placenta? A retrospective appraisal Infectious causes of morbidity and mortality in the newborn are well documented, but the relationship of this to placental infection is not well known yet. Having the Ethical Comitee consent for the study, from the medical archives of University Emergency Hospital in Bucharest, Department of Pathology, and the Department of Obstretics and Gynaecology, fiftyseven placentas were selected over a period of 22 months. In this study there have been 15 (26.31%) cases of acute chorioamnionitis (COA) and 31 (73.68%) cases of chronic chorioamnionitis (COC), with an overall mean gestational age of 27.6 weeks. The cases with COA were having mean gestational age of 26.5 weeks (6-38 weeks), only five living new-born with a mean gestational age of 35.3 weeks. In the study, there were documented 10 abortions (17,54%) with a mean gestational age of 12 weeks. Most pathologic cases proved histologic abnormalities such as fibrinoid necrosis of villi, villitis, villous edema, few Hofbauer cells, villous or fetal changes, vasculosyncytial knots, that differentiated the cases from those with normal histology by a increased gestational age with a mean of 32.25 weeks. We conclude that a moderate degree of placental inflammatory status will not influence significantly the degree of hypoxia.

Loading...

Loading Preview

Sorry, preview is currently unavailable. You can download the paper by clicking the button above.

References (13)

  1. you D, Bastian P, Wu J. Committing to Child Survival: A Promise Renewed - Progress Report 2013. New york. UNICEF, 2013, in press.
  2. Duncan GJ, Brooks-Gunn J. Family Poverty, Welfare Reform, and Child Development,Child Development 71, Vol. 1, pag. 188-96.
  3. Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis.Nature Methods 2012, 9(7), 671-5.
  4. Shivanandan A, Radenovic A, Sbalzarini IF. MosaicIA: an ImageJ/Fiji plugin for spatial pattern and interaction analysis. BMC Bioinformatics 2013, 14, 349.
  5. Rasband WS. ImageJ. U. S. National Institutes of Health, Bethesda, Maryland, USA, 2014. Available athttp://imagej.nih.gov/ij/.
  6. Abramoff MD, Magalhaes PJ, Ram SJ. Image Processing with ImageJ. Biophotonics International 2004, 11(7), 36-42.
  7. Fabry ME, Kaul DK, Raventos C, Baez S, Rieder R, Nagel RL. Some aspects of the pathophysiology of homozygous Hb CC erythrocytes. J Clin Invest 1981, 67(5),1284-91.
  8. Pfisterer C, Faber R, Hor LC. Chorioamnionitis-induced changes of fetal extramedullar hematopoiesisin the second trimester of gestation.Is diagnosis from fetal autopsy possible?Virchows Arch 2005, 446,150-6.
  9. Stallmach T, Hebisch G. Placentalpathology: its impact on explaining prenataland perinatal death. Virchows Arch 2004, 445,9-16.
  10. Mingrone R, Fulcheri E, Lavezzi AM, Matturri L. Chorioamnionitis and Congenital Abnormalities of the Brainstem (Arcuate Nucleus and Pre- Bötzinger Complex Hypoplasia) in a Case of Late Unexplained Stillbirth.The Open Pathology Journal 2008, 2, 24-7.
  11. Gantert M, Been JV, Gavilanes AW, Garnier y, Zimmermann LJ, Kramer BW. Chorioamnionitis: a multiorgan disease of the fetus?. J Perinatol 2010, S21-30.
  12. Jacques SM, Qureshi F. Chronic chorioamnionitis: a clinicopathologic and immunohistochemical study. Human Pathlogy 1999, 29(12),1457-61.
  13. Lee J, Kim JS, Park JW, Park CW, Park JS, Jun JK, yoon BH. Chronic chorioamnionitis is the most common placental lesion in late preterm birth. Placenta 2013, 34(8), 681-9.