Recruitment of Marrow Donors in the Non-governmental Sector of the Republic of North Macedonia, 2022 (original) (raw)
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Cell and Tissue Banking, 2021
Allogeneic stem cell transplantation (SCT) offers a potential cure for some hematological malignancies. For those patients without a family donor, unrelated donor (MUD) registries serve for identifying the best donor. In the present study, we aimed to give a cross-sectional report of our registry's activity and experience as the first established national MUD registry in the country. The study is retrospective and covers the period of 2016 to 2019. A total of 1855 donor searches were performed, and 642 were included in the study. All data were electronically obtained from the institutional database system. All SCTs were either 10/10 or 9/10 HLA matched and originated from an international registry. The most preferred stem cell source was peripheral blood (70.2%). A quarter of transplants were performed using bone marrow, and cord blood was used with a rate of 1.4%. The pandemic-related problems were similar for the other two national registries. During the pandemic, 71 of 432 pa...
Bulgarian Bone Marrow Donors Registry—past and future directions
Cell and Tissue Banking, 2007
Recently Bulgarian Bone Marrow Donors Registry (BBMDR) has been established and since August 2005 it has been a member of Bone Marrow Donors Worldwide. Currently the number of healthy donors included in the BBMDR is relatively low. All donors included in the BBMDR are typed for HLA-A, -B, -DRB loci. Phylogenetic analysis based on HLA allele frequencies shows that Bulgarians were characterized with closest genetic similarity to Macedonians, Greeks, Romanians, Cretans and Sardinians in comparison to the other European and Mediterranean populations. On the contrary the second largest ethnic minority-the Roma were the closest to the other Roma populations and North Indians. These differences were due to the predominance of alleles and haplotypes that are specific for the Asian and the other Roma populations. These specific genetic profiles in the Bulgarian ethnic minorities justify the need of an adequate representation of minorities in BBMDR. Future directions for BBMDR development are discussed, including an increase of the total number of donors and these for ethnic minorities, as well the enhancement of the level of resolution of the HLA typing for the donors in the registry.
Transfusion Medicine and Hemotherapy, 2011
Background: The Austrian Bone Marrow Donor Registry is the central search coordinating unit in charge of national and international donor searches in Austria. Patients and Methods: Between 1988 and 2010, a worldwide search for an unrelated donor of blood stem cells (URD) was initiated for 2,166 Austrian patients with haematological disorders, 1,671 adults and 495 children, by the Austrian Bone Marrow Donor Registry. Results: An URD was identified for 78.3% of the patients between 2008 and 2010, for 76.7% of the patients between 2004 and 2007, for 71.3% between 1996 and 2003, but only for 53.4% of the patients in the initial period of 1988-1995. Thus, results of international donor searches improve over time. In contrast, search duration decreases steadily: Search times of successful searches decreased from about 8 months in the first period between 1988 and 1996 to 1.84 months in 2010. Overall, 1,558 of the 2,166 patients (71.9%) could be provided with a matching donor. However, not every patient provided with a URD was transplanted. Overall, only 1,141 of 2,166 patients (52.7%) proceeded to transplant. Conclusion: Figures have significantly improved for the latest period of donor searches between 2008 and 2010. In this period, a donor could be found for 78.3%, and 58.5% of the patients received a transplant. Schlüsselwörter Nichtverwandter Blutstammzellenspender · URD · MUD · Internationale Spendersuche · Hämatopoetische Stammzelltransplantation Zusammenfassung Hintergrund: Das Österreichische Stammzell-Register ist die zentrale Suchkoordinierungsstelle für die nationale und internationale Spendersuche in Österreich. Patienten und Methoden: Zwischen 1998 und 2010 wurde eine weltweite Suche für nichtverwandte Spender von Blutstammzellen (unrelated donors of blood stem cells; URD) für 2166 österreichische Patienten mit hämatologischen Erkrankungen (1671 Erwachsene, 495 Kinder) durch das Österreichische Stammzell-Register initiiert. Ergebnisse: Für 78,3% der Patienten konnte zwischen 2008 und 2010 ein URD identifiziert werden; zwischen 1996 und 2003 gelang dies für 71,3%. Während der Initiierungsphase zwischen 1988 und 1995 gelang dies hingegen nur 53,4% der Patienten. Die Ergebnisse der internationalen Spendersuche verbesserten sich also über die Zeit. Gleichzeitig nahm die Suchdauer kontinuierlich ab: Die Suchzeiten für erfolgreiche Suchen sanken von 8 Monaten in der ersten Phase zwischen 1988 und 1996 auf 1,84 Monate im Jahr 2010. Insgesamt konnten 1558 von 2166 Patienten mit einem passenden Spender versorgt werden. Allerdings wurde nicht jeder Patient, für den ein URD gefunden wurde, tatsächlich transplantiert. Insgesamt 1141 von 2166 (52,7%) Patienten erhielten eine Knochenmarkspende. Schlussfolgerung: Die Zahlen haben sich für die letzte Spendersuchperiode zwischen 2008 und 2010 deutlich verbessert.
Transfusion, 1986
Because of recent increases in bone marrow transplantation, the lack of available matched sibling donors has become a problem. This study investigated the feasibility of obtaining volunteer bone marrow donors unrelated to the patient. A program was developed to inform potential donors and obtain their consent for listing in a bone marrow donor registry. Sixty-six percent of whole blood or apheresis donors agreed to participate in the program. There were no demographic differences between those who accepted or declined to participate. Religion, experiences with medical practices, and the attitude of the potential donor's spouse were important factors in the decision to participate. A search for donors was initiated for 127 patients. Thirty searches were not completed, primarily because of patient-related problems. A total of 713 HLA-A and -B antigen-identical donors was located for 63 of the 97 (65%) patients. A total of 40 HLA-A, -B, and -DR antigen-identical donors was located for 18 of these 63 patients. Six of these 18 patients then had one or more donors (total, 9) whose lymphocytesdid not react in mixed lymphocyteculture. Thus, using the file of 2147 donors, an HLA-identical donor was located for 6 percent of the97 patients. None of these patients has yet received a transplant; in four cases this was due to patient-related and in two cases donor-related reasons. The cost to establish the donor program averaged $33.46 (1984) per donor for donors already typed for HLA-A and -B antigens. This experience indicated that, given thorough information about bone marrow donation and transplantation, a majority of blood and apheresis donors will volunteer to donate bone marrow, without feeling pressure to do so. A relatively small donor file provided donors for6 percent of patients. The long-term value of bone marrow transplantation using unrelated donors and the optimum size of the donor file remain to be established. TRANSFUSION 1986;26:315-323.
Blood and marrow transplantation activity in Europe 1995
1997
Keywords: bone marrow transplant; peripheral blood stem cell transplant; epidemiology; transplant activity; Europe; coefficient of variation In 1995, a total of 12 101 blood or marrow transplants, performed in Europe by 343 teams from 31 countries, were reported to the European Group for Blood and Marrow Transplantation (EBMT). Of these, 3858 (32%)
The National Marrow Donor Program
Transfusion, 1993
As the number of successful marrow transplants has increased, the lack of HLAidentical sibling donors for 60 to 70 percent of transplant candidates has become a serious problem. Pilot studies established that marrow transplantation between phenotypically HLA-identical, unrelated individuals can be accomplished successfully. Therefore, the National Marrow Donor Program was established to develop a lar e donor search and donor-recipient matching rocesses. By November 1991, 63
Factors That Influence Greeks' Decision to Register as Potential Bone Marrow Donors
Transplantation Proceedings, 2008
Hemopoietic stem cells can be used from bone marrow or blood or umbilical cord blood of matched siblings or appropriately matched unrelated volunteers. Today, large bone marrow registries have been established to help identify volunteer unrelated bone marrow donors for patients lacking a family donor. Despite there being almost 10 million registered potential bone marrow donors (PBMD) worldwide, only 50% of white patients have a suitable bone marrow match. Growth in the number of PBMD increases the likelihood of finding a compatible donor for a patient. The attitudes and knowledge of 250 registered PBMD and 315 not registered PBMD toward bone marrow donation, tissues and organs donation, and blood donation were surveyed, using a questionnaire with 27 items. Multivariate logistic regression identified gender (females more often than males), regular blood donation, having a relative or a friend who has already been registered as PBMD, having a relative or a friend who needs bone marrow transplantation, family discussion about tissue and organ donation, knowledge about bone marrow transplantation, information about bone marrow transplantation, and trust in health professionals were independent predictive factors influencing people's decision to register as PBMD.
Transplantation Proceedings, 2016
History of hematopoietic stem cell transplantations in Poland begins in early 1980s; the 1st bone marrow allotransplantation was performed in 1983 in the Central Clinical Hospital of the Military Medical Academy in Warsaw. Following years brought the 1st autologous stem cell transplantations. Ten years later, unrelated bone marrow transplantation was performed for the 1st time by the team of the Hematology and Blood and Marrow Transplantation Unit in Katowice. Since then, hematopoietic stem cell transplantation developed to be standard procedure and one of the most important therapies applied in leukemia treatment. The number of allotransplantations in Poland has grown significantly in the past 2 decades, which generated new needs and problems. In 2005, based on a new Transplant Law, a National Transplants Registry was created. Its main role is to collect data (registration of procedures and follow-up data) related to every transplantation case for stem cells and tissues as well as for organs. We present statistics concerning stem cell transplantations performed in Poland, as collected in the National Transplants Registry in the years 2006e2014. There are 18 centers transplanting hematopoietic stem cells in Poland. The total number of hematopoietic stem cell transplantations performed in 2006e2014 was 3,537, with allotransplantations from relatives accounted for 1,491 and from unrelated donors for 2,046. The main indication for allotransplantation in past years was acute leukemia.